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Relation of medication adherence to cognitive functions in egyptian patients with bipolar I disorder.
Khalil, Afaf Hamed; El Shahawi, Heba Hamed; Abdelgawad, Ahmed Saber; Abdeen, Mai SeifElDin; El Serafi, Doha Mustafa; Khalil, Sherien Ahmed.
Afiliación
  • Khalil AH; Psychiatry Department, Faculty of Medicine, Ain Shams University.
  • El Shahawi HH; Psychiatry Department, Faculty of Medicine, Ain Shams University.
  • Abdelgawad AS; General Secretariat of Mental Health and Addiction Treatment, Ministry of Health and Population, Egypt.
  • Abdeen MS; Psychiatry Department, Faculty of Medicine, Ain Shams University.
  • El Serafi DM; Psychiatry Department, Faculty of Medicine, Ain Shams University.
  • Khalil SA; Psychiatry Department, Faculty of Medicine, Ain Shams University.
Int Clin Psychopharmacol ; 36(4): 193-200, 2021 07 01.
Article en En | MEDLINE | ID: mdl-33724253
Nonadherence to medication regimens is frequently reported in bipolar I disorder (BDI) patients. However, little is known about the relationship between cognitive functions and adherence in BDI. To establish possible associations between medication adherence and cognitive function in patients with BDI. A total of 110 inpatients with BDI were subjected to the Structured Clinical Interview for DSM-IV Axis I Disorder, Morisky 8-Item Medication Adherence Scale, Young Mania Rating Scale, Wechsler Adult Intelligence Scale-Revised, Wechsler memory scale (WMS) and Wisconsin card sorting test (WCST). Patients were assessed on admission and followed up 6 months after discharge. Six months after discharge, (58.2%) of patients were nonadherent to their medications. The nonadherent group were younger males with less years of education, with lower mean scores in information orientation and visual memory backward domains of WMS and lower mean scores in perseveration responses, perseveration errors and learning to learn domains of WCST. In logistic regression analysis, younger age and impaired information orientation domain of WMS were putative predictors of nonadherence. Episodic memory and younger age were the strongest patients' related factors associated with nonadherence to medication. These results suggest that rehabilitation of specific cognitive skills may improve adherence in BDI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Cognición / Cumplimiento de la Medicación Tipo de estudio: Prognostic_studies / Qualitative_research Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Int Clin Psychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Cognición / Cumplimiento de la Medicación Tipo de estudio: Prognostic_studies / Qualitative_research Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Int Clin Psychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido