Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors.

See, Ji-Eun; Shin, Ha Rim; Jang, Gayoung; Kweon, Jiyeon; Kim, Yongsub

See, Ji-Eun; Shin, Ha Rim; Jang, Gayoung; Kweon, Jiyeon; Kim, Yongsub.

Afiliación

See JE; Department of Biomedical Sciences, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine; Stem Cell Immunomodulation Research Center, University of Ulsan College of Medicine.
Shin HR; Department of Biomedical Sciences, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine; Stem Cell Immunomodulation Research Center, University of Ulsan College of Medicine.
Jang G; Department of Biomedical Sciences, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine; Stem Cell Immunomodulation Research Center, University of Ulsan College of Medicine.
Kweon J; Department of Biomedical Sciences, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine; Stem Cell Immunomodulation Research Center, University of Ulsan College of Medicine; jiyeon1015@gmail.com.
Kim Y; Department of Biomedical Sciences, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine; Stem Cell Immunomodulation Research Center, University of Ulsan College of Medicine; yongsub1.kim@gmail.com.

J Vis Exp ; (168)2021 02 28.

Article en En | MEDLINE | ID: mdl-33720123

Asunto(s)

Proteína BRCA1/genética; Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas/genética; Edición Génica; Variación Genética; Secuencia de Bases; Neoplasias de la Mama/genética; Proteína 9 Asociada a CRISPR/metabolismo; Línea Celular Tumoral; Femenino; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; ARN Guía de Kinetoplastida/genética

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Proteína BRCA1 / Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas / Edición Génica Tipo de estudio: Guideline Límite: Female / Humans Idioma: En Revista: J Vis Exp Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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