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Extracellular vesicles derived from macrophages display glycyl-tRNA synthetase 1 and exhibit anti-cancer activity.
Goughnour, Peter C; Park, Min Chul; Kim, Sang Bum; Jun, Sangmi; Yang, Won Suk; Chae, Sehyun; Cho, Seongmin; Song, Chihong; Lee, Ji-Hyun; Hyun, Jae Kyung; Kim, Byung Gyu; Hwang, Daehee; Jung, Hyun Suk; Gho, Yong Song; Kim, Sunghoon.
Afiliación
  • Goughnour PC; Institute for Artificial Intelligence and Biomedical Research Medicinal Bioconvergence Research Center College of Pharmacy & College of Medicine Gangnam Severance Hospital Yonsei University Incheon Korea.
  • Park MC; Institute for Artificial Intelligence and Biomedical Research Medicinal Bioconvergence Research Center College of Pharmacy & College of Medicine Gangnam Severance Hospital Yonsei University Incheon Korea.
  • Kim SB; Institute for Artificial Intelligence and Biomedical Research Medicinal Bioconvergence Research Center College of Pharmacy & College of Medicine Gangnam Severance Hospital Yonsei University Incheon Korea.
  • Jun S; Division of Electron Microscopic Research Korea Basic Science Institute Daejeon Korea.
  • Yang WS; Institute for Artificial Intelligence and Biomedical Research Medicinal Bioconvergence Research Center College of Pharmacy & College of Medicine Gangnam Severance Hospital Yonsei University Incheon Korea.
  • Chae S; Daegu Gyeongbuk Institute of Science and Technology Daegu Korea.
  • Cho S; Institute for Artificial Intelligence and Biomedical Research Medicinal Bioconvergence Research Center College of Pharmacy & College of Medicine Gangnam Severance Hospital Yonsei University Incheon Korea.
  • Song C; Division of Electron Microscopic Research Korea Basic Science Institute Daejeon Korea.
  • Lee JH; Institute for Artificial Intelligence and Biomedical Research Medicinal Bioconvergence Research Center College of Pharmacy & College of Medicine Gangnam Severance Hospital Yonsei University Incheon Korea.
  • Hyun JK; Division of Electron Microscopic Research Korea Basic Science Institute Daejeon Korea.
  • Kim BG; Institute for Artificial Intelligence and Biomedical Research Medicinal Bioconvergence Research Center College of Pharmacy & College of Medicine Gangnam Severance Hospital Yonsei University Incheon Korea.
  • Hwang D; Center for Genomic Integrity Institute for Basic Science Ulsan Korea.
  • Jung HS; Daegu Gyeongbuk Institute of Science and Technology Daegu Korea.
  • Gho YS; Department of Biochemistry College of Natural Sciences Kangwon National University Chuncheon Korea.
  • Kim S; Department of Life Science Pohang University of Science and Technology Pohang Korea.
J Extracell Vesicles ; 10(1): e12029, 2020 11.
Article en En | MEDLINE | ID: mdl-33708357
Glycyl-tRNA synthetase 1 (GARS1), a cytosolic enzyme secreted from macrophages, promotes apoptosis in cancer cells. However, the mechanism underlying GARS1 secretion has not been elucidated. Here, we report that GARS1 is secreted through unique extracellular vesicles (EVs) with a hydrodynamic diameter of 20-58 nm (mean diameter: 36.9 nm) and a buoyant density of 1.13-1.17 g/ml. GARS1 was anchored to the surface of these EVs through palmitoylated C390 residue. Proteomic analysis identified 164 proteins that were uniquely enriched in the GARS1-containing EVs (GARS1-EVs). Among the identified factors, insulin-like growth factor II receptor, and vimentin also contributed to the anti-cancer activity of GARS1-EVs. This study identified the unique secretory vesicles containing GARS1 and various intracellular factors that are involved in the immunological defence response against tumorigenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Proteínas Supresoras de Tumor / Vesículas Extracelulares / Glicina-ARNt Ligasa / Macrófagos / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Extracell Vesicles Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Proteínas Supresoras de Tumor / Vesículas Extracelulares / Glicina-ARNt Ligasa / Macrófagos / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Extracell Vesicles Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos