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Changes of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study.
Lee, Geun Woo; Ryu, Sukhyun; Park, Juhee; Lee, Eun Jee; Lee, Kwang Jun; Tae, Jungyeon; Hwang, Youngsik; Kim, Dong-Sook.
Afiliación
  • Lee GW; Pharmaceutical and Medical Technology Research Team, Department of Research, Health Insurance Review and Assessment Service, Wonju, South Korea.
  • Ryu S; Department of Preventive Medicine, Konyang University College of Medicine, Daejeon, South Korea.
  • Park J; Pharmaceutical and Medical Technology Research Team, Department of Research, Health Insurance Review and Assessment Service, Wonju, South Korea.
  • Lee EJ; Pharmaceutical and Medical Technology Research Team, Department of Research, Health Insurance Review and Assessment Service, Wonju, South Korea.
  • Lee KJ; National Institute of Health, Korean Centers for Disease Control and Prevention, Osong, South Korea.
  • Tae J; Department of Preventive Medicine, Konyang University College of Medicine, Daejeon, South Korea.
  • Hwang Y; Department of Preventive Medicine, Konyang University College of Medicine, Daejeon, South Korea.
  • Kim DS; Pharmaceutical and Medical Technology Research Team, Department of Research, Health Insurance Review and Assessment Service, Wonju, South Korea. sttone@hira.or.kr.
Sci Rep ; 11(1): 5658, 2021 03 11.
Article en En | MEDLINE | ID: mdl-33707496
In the present study, we investigated the pattern of changes in antibiotic prescription and antimicrobial resistance (AMR) in Escherichia coli in South Korea between 2007 and 2018. We collected data related to antibiotic prescription and AMR in E. coli from the national surveillance system. We used the Mann-Kendall test and Spearman's correlation to identify the trends of antibiotic prescription and AMR in E. coli and to examine the relationship between them, respectively. Although we noted a significant decreasing trend of ampicillin and gentamicin prescriptions in all medical institutions, we identified a higher level of AMR in long-term care facilities than in other medical institutions. We did not identify a significant positive correlation between ampicillin and gentamicin prescriptions and their resistance in E. coli. However, we found a significant positive correlation between cefotaxime prescription and its resistance in E. coli in hospitals, long-term care facilities, and clinics. Our results strongly suggest that long-term care facilities in South Korea have the potential to sustain AMR epidemics and that more efforts are needed to curb AMR in E. coli. Further epidemiological studies using enhanced AMR surveillance are warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prescripciones de Medicamentos / Pautas de la Práctica en Medicina / Escherichia coli / Antibacterianos Tipo de estudio: Observational_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prescripciones de Medicamentos / Pautas de la Práctica en Medicina / Escherichia coli / Antibacterianos Tipo de estudio: Observational_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido