Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease.

Zhao, Rui; Zhang, Wei; Ma, Chenghong; Zhao, Yaping; Xiong, Rong; Wang, Hanmin; Chen, Weiwen; Zheng, Song Guo

Zhao, Rui; Zhang, Wei; Ma, Chenghong; Zhao, Yaping; Xiong, Rong; Wang, Hanmin; Chen, Weiwen; Zheng, Song Guo.

Afiliación

Zhao R; Department of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, China.
Zhang W; Department of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, China.
Ma C; Department of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, China.
Zhao Y; Department of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, China.
Xiong R; Department of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, China.
Wang H; Department of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, China.
Chen W; Department of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, China.
Zheng SG; Division of Immunology and Rheumatology, Ohio State University Wexner Medical Center and College of Medicine, Columbus, OH, United States.

Front Immunol ; 12: 574967, 2021.

Article en En | MEDLINE | ID: mdl-33679732

RESUMEN

Vitamin D is one of the most important nutrients required by the human body. It is a steroid hormone that plays an important role in regulating calcium and phosphorus metabolism, and bone health. Epidemiological studies have revealed a close correlation between vitamin D and many common chronic diseases. Additionally, vitamin D has recently been shown to act as an immunomodulatory hormone, and, accordingly, vitamin D deficiency was uncovered as a risk factor for autoimmune thyroid diseases, although the underlying mechanisms are still unknown. It is therefore necessary to disclose the role and mechanism of action of vitamin D in the occurrence and development of autoimmune thyroid diseases. This knowledge will help design intervention and early treatment strategies for patients with autoimmune thyroid diseases who present with low levels of vitamin D.

Asunto(s)

Enfermedad de Hashimoto/metabolismo; Factores Inmunológicos/metabolismo; Tiroiditis Autoinmune/metabolismo; Deficiencia de Vitamina D/metabolismo; Vitamina D/metabolismo; Enfermedad de Hashimoto/fisiopatología; Enfermedad de Hashimoto/prevención & control; Humanos; Factores Inmunológicos/uso terapéutico; Receptores de Calcitriol/metabolismo; Factores de Riesgo; Pruebas de Función de la Tiroides; Tiroiditis Autoinmune/fisiopatología; Tiroiditis Autoinmune/prevención & control; Vitamina D/sangre; Vitamina D/uso terapéutico; Deficiencia de Vitamina D/prevención & control; Vitaminas/sangre; Vitaminas/metabolismo; Vitaminas/uso terapéutico

Palabras clave

Grave's disease; Hashimoto autoimmune thyroiditis; autoimmune thyroid disease; immunomodulatory function; vitamin D

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina D / Deficiencia de Vitamina D / Tiroiditis Autoinmune / Enfermedad de Hashimoto / Factores Inmunológicos Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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