Epigenetic regulation of p62/SQSTM1 overcomes the radioresistance of head and neck cancer cells via autophagy-dependent senescence induction.

Lee, Myungjin; Nam, Hae Yun; Kang, Hee-Bum; Lee, Won Hyeok; Lee, Geun-Hee; Sung, Gi-Jun; Han, Myung Woul; Cho, Kyung-Ja; Chang, Eun-Ju; Choi, Kyung-Chul; Kim, Seong Who; Kim, Sang Yoon

Lee, Myungjin; Nam, Hae Yun; Kang, Hee-Bum; Lee, Won Hyeok; Lee, Geun-Hee; Sung, Gi-Jun; Han, Myung Woul; Cho, Kyung-Ja; Chang, Eun-Ju; Choi, Kyung-Chul; Kim, Seong Who; Kim, Sang Yoon.

Afiliación

Lee M; Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Nam HY; Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Kang HB; New Drug R&D Center, HLB LifeScience, Hwaseong, Republic of Korea.
Lee WH; Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
Lee GH; Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Sung GJ; Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Han MW; Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, MI, USA.
Cho KJ; Department of Otorhinolaryngology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
Chang EJ; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Choi KC; Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Kim SW; Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Kim SY; Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. choikc75@amc.seoul.kr.

Cell Death Dis ; 12(3): 250, 2021 03 05.

Article en En | MEDLINE | ID: mdl-33674559

Asunto(s)

Autofagia/efectos de los fármacos; Senescencia Celular/efectos de la radiación; Epigénesis Genética; Neoplasias de Cabeza y Cuello/radioterapia; Tolerancia a Radiación; Proteína Sequestosoma-1/metabolismo; Carcinoma de Células Escamosas de Cabeza y Cuello/radioterapia; Acetilación; Animales; Línea Celular Tumoral; Ensamble y Desensamble de Cromatina; Islas de CpG; ADN (Citosina-5-)-Metiltransferasa 1/metabolismo; Metilación de ADN; Regulación Neoplásica de la Expresión Génica; Heterogeneidad Genética; Neoplasias de Cabeza y Cuello/genética; Neoplasias de Cabeza y Cuello/metabolismo; Neoplasias de Cabeza y Cuello/patología; Histona Desacetilasa 1/metabolismo; Humanos; Masculino; Ratones Desnudos; Regiones Promotoras Genéticas; Tolerancia a Radiación/genética; Proteína Sequestosoma-1/genética; Transducción de Señal; Carcinoma de Células Escamosas de Cabeza y Cuello/genética; Carcinoma de Células Escamosas de Cabeza y Cuello/metabolismo; Carcinoma de Células Escamosas de Cabeza y Cuello/patología; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tolerancia a Radiación / Autofagia / Senescencia Celular / Epigénesis Genética / Proteína Sequestosoma-1 / Carcinoma de Células Escamosas de Cabeza y Cuello / Neoplasias de Cabeza y Cuello Límite: Animals / Humans / Male Idioma: En Revista: Cell Death Dis Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido

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