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Toxicity Profiling of Biosurfactants Produced by Novel Marine Bacterial Strains.
Voulgaridou, Georgia-Persephoni; Mantso, Theodora; Anestopoulos, Ioannis; Klavaris, Ariel; Katzastra, Christina; Kiousi, Despoina-Eugenia; Mantela, Marini; Galanis, Alex; Gardikis, Konstantinos; Banat, Ibrahim M; Gutierrez, Tony; Salek, Karina; Euston, Stephen; Panayiotidis, Mihalis I; Pappa, Aglaia.
Afiliación
  • Voulgaridou GP; Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Mantso T; Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK.
  • Anestopoulos I; Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Klavaris A; Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Katzastra C; Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Kiousi DE; Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Mantela M; Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Galanis A; Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Gardikis K; Research and Development Department, APIVITA SA, Industrial Park Markopoulo Mesogaias, 19003 Athens, Greece.
  • Banat IM; Pharmaceutical Science Research Group, Biomedical Science Research Institute, Ulster University, Coleraine, Northern Ireland BT52 1SA, UK.
  • Gutierrez T; Institute of Mechanical, Process & Energy Engineering, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.
  • Salek K; Institute of Biological Chemistry, Biophysics & Bioengineering, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.
  • Euston S; Institute of Biological Chemistry, Biophysics & Bioengineering, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.
  • Panayiotidis MI; Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK.
  • Pappa A; The Cyprus Institute of Neurology and Genetics, Department of Cancer Genetics, Therapeutics and Ultrastructural Pathology, Nicosia 2371, Cyprus.
Int J Mol Sci ; 22(5)2021 Feb 27.
Article en En | MEDLINE | ID: mdl-33673549
Surface active agents (SAAs), currently used in modern industry, are synthetic chemicals produced from non-renewable sources, with potential toxic impacts on humans and the environment. Thus, there is an increased interest for the identification and utilization of natural derived SAAs. As such, the marine environment is considered a promising source of biosurfactants with low toxicity, environmental compatibility, and biodegradation compared to their synthetic counterparts. MARISURF is a Horizon 2020 EU-funded project aiming to identify and functionally characterize SAAs, derived from a unique marine bacterial collection, towards commercial exploitation. Specifically, rhamnolipids produced by Marinobacter MCTG107b and Pseudomonas MCTG214(3b1) strains were previously identified and characterized while currently their toxicity profile was assessed by utilizing well-established methodologies. Our results showed a lack of cytotoxicity in in vitro models of human skin and liver as indicated by alamar blue and propidium iodide assays. Additionally, the use of the single gel electrophoresis assay, under oxidative stress conditions, revealed absence of any significant mutagenic/anti-mutagenic potential. Finally, both 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonicacid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) cell-free assays, revealed no significant anti-oxidant capacity for neither of the tested compounds. Consequently, the absence of significant cytotoxicity and/or mutagenicity justifies their commercial exploitation and potential development into industrial end-user applications as natural and environmentally friendly biosurfactants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tensoactivos / Bacterias / Queratinocitos / Neoplasias Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tensoactivos / Bacterias / Queratinocitos / Neoplasias Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza