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Titers of Neutralizing Antibodies against SARS-CoV-2 Are Independent of Symptoms of Non-Severe COVID-19 in Young Adults.
Jonsdottir, Hulda R; Bielecki, Michel; Siegrist, Denise; Buehrer, Thomas W; Züst, Roland; Deuel, Jeremy W.
Afiliación
  • Jonsdottir HR; SPIEZ Laboratory, Austrasse, 3700 Spiez, Switzerland.
  • Bielecki M; Swiss Armed Forces, Medical Services, Worblentalstrasse, 3063 Ittigen, Switzerland.
  • Siegrist D; Epidemiology, Biostatistics and Prevention Institute, Travel Clinic, Hirschengraben, University of Zurich, 8006 Zürich, Switzerland.
  • Buehrer TW; SPIEZ Laboratory, Austrasse, 3700 Spiez, Switzerland.
  • Züst R; Swiss Armed Forces, Medical Services, Worblentalstrasse, 3063 Ittigen, Switzerland.
  • Deuel JW; SPIEZ Laboratory, Austrasse, 3700 Spiez, Switzerland.
Viruses ; 13(2)2021 02 12.
Article en En | MEDLINE | ID: mdl-33673067
Neutralizing antibodies are an important part of the humoral immune response to SARS-CoV-2. It is currently unclear to what extent such antibodies are produced after non-severe disease or asymptomatic infection. We studied a cluster of SARS-CoV-2 infections among a homogeneous population of 332 predominantly male Swiss soldiers and determined the neutralizing antibody response with a serum neutralization assay using a recombinant SARS-CoV-2-GFP. All patients with non-severe COVID-19 showed a swift humoral response within two weeks after the onset of symptoms, which remained stable for the duration of the study. One month after the outbreak, titers in COVID-19 convalescents did not differ from the titers of asymptomatically infected individuals. Furthermore, symptoms of COVID-19 did not correlate with neutralizing antibody titers. Therefore, we conclude that asymptomatic infection can induce the same humoral immunity as non-severe COVID-19 in young adults.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticuerpos Neutralizantes / Inmunidad Humoral / Infecciones Asintomáticas / COVID-19 / Anticuerpos Antivirales Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Viruses Año: 2021 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticuerpos Neutralizantes / Inmunidad Humoral / Infecciones Asintomáticas / COVID-19 / Anticuerpos Antivirales Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Viruses Año: 2021 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Suiza