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Vitamin D Signaling in Gastro-Rheumatology: From Immuno-Modulation to Potential Clinical Applications.
Pagnini, Cristiano; Picchianti-Diamanti, Andrea; Bruzzese, Vincenzo; Lorenzetti, Roberto; Luchetti, Michele Maria; Martin, Louis Severino Martin; Pica, Roberta; Scolieri, Palma; Scribano, Maria Lia; Zampaletta, Costantino; Chimenti, Maria Sole; Lagana, Bruno.
Afiliación
  • Pagnini C; Department of Gastroenterology and Digestive Endoscopy, S. Giovanni Addolorata Hospital, 00184 Rome, Italy.
  • Picchianti-Diamanti A; Department of Clinical and Molecular Medicine, S. Andrea University Hospital, Sapienza University, 00189 Rome, Italy.
  • Bruzzese V; Department of Internal Medicine, Rheumatology and Gastroenterology, Nuovo Regina Margherita Hospital, 00153 Rome, Italy.
  • Lorenzetti R; Department of Internal Medicine, Rheumatology and Gastroenterology, Nuovo Regina Margherita Hospital, 00153 Rome, Italy.
  • Luchetti MM; Clinica Medica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, 60131 Ancona, Italy.
  • Martin LSM; Ospedale Regina Apostolorum, U.O. di Medicina Interna e Reumatologia, 00041 Albano Laziale, Italy.
  • Pica R; Unit of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, 00157 Rome, Italy.
  • Scolieri P; Department of Internal Medicine, Rheumatology and Gastroenterology, Nuovo Regina Margherita Hospital, 00153 Rome, Italy.
  • Scribano ML; Gastroenterology Unit, AO San Camillo Forlanini, 00152 Rome, Italy.
  • Zampaletta C; Division of Gastroenterology, "Belcolle" Hospital, 01100 Viterbo, Italy.
  • Chimenti MS; Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, 00187 Rome, Italy.
  • Lagana B; Department of Clinical and Molecular Medicine, S. Andrea University Hospital, Sapienza University, 00189 Rome, Italy.
Int J Mol Sci ; 22(5)2021 Feb 28.
Article en En | MEDLINE | ID: mdl-33671090
In the last decades, the comprehension of the pathophysiology of bone metabolism and its interconnections with multiple homeostatic processes has been consistently expanded. The branch of osteoimmunology specifically investigating the link between bone and immune system has been developed. Among molecular mediators potentially relevant in this field, vitamin D has been recently pointed out, and abnormalities of the vitamin D axis have been described in both in vitro and in vivo models of inflammatory bowel diseases (IBD) and arthritis. Furthermore, vitamin D deficiency has been reported in patients affected by IBD and chronic inflammatory arthritis, thus suggesting the intriguing possibility of impacting the disease activity by the administration vitamin D supplements. In the present review, the complex interwoven link between vitamin D signaling, gut barrier integrity, microbiota composition, and the immune system was examined. Potential clinical application exploiting vitamin D pathway in the context of IBD and arthritis is presented and critically discussed. A more detailed comprehension of the vitamin D effects and interactions at molecular level would allow one to achieve a novel therapeutic approach in gastro-rheumatologic inflammatory diseases through the design of specific trials and the optimization of treatment protocols.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Vitamina D / Deficiencia de Vitamina D / Vitaminas / Enfermedades Inflamatorias del Intestino / Enfermedades Gastrointestinales Tipo de estudio: Etiology_studies / Guideline Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Vitamina D / Deficiencia de Vitamina D / Vitaminas / Enfermedades Inflamatorias del Intestino / Enfermedades Gastrointestinales Tipo de estudio: Etiology_studies / Guideline Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza