Your browser doesn't support javascript.
loading
Increased interleukin-11 associated with disease activity and development of interstitial lung disease in patients with rheumatoid arthritis.
Wang, Xiaoqin; Zhu, Gongmin; Ren, Qijie; Wu, Jing; Gu, Bingjie; Su, Dinglei; Shen, Minning.
Afiliación
  • Wang X; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Jiangsu Province, China.
  • Zhu G; Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Jiangsu Province, China.
  • Ren Q; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Jiangsu Province, China.
  • Wu J; Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Jiangsu Province, China.
  • Gu B; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Jiangsu Province, China.
  • Su D; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Jiangsu Province, China. sudinglei@163.com.
  • Shen M; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Jiangsu Province, China. shenminning@126.com.
Clin Exp Rheumatol ; 40(1): 135-141, 2022 01.
Article en En | MEDLINE | ID: mdl-33666155
OBJECTIVES: To investigate the association of serum interleukin-11 (IL-11) with disease activity and occurrence of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA). METHODS: One hundred and six RA patients were included, including 31 with ILD. All patients were divided into two groups according to the 28-joint Disease Activity Score (DAS28), active-disease group (DAS28>3.2) and target-achieved group (DAS28≤3.2). Serum IL-11 was detected by ELISA. Serum autoantibodies [anticitrullinated protein antibody (ACPA) and rheumatoid factor (RF)], inflammatory markers [C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)], and complete blood count were measured with routine methods. RESULTS: Serum IL-11 was upregulated in RA patients compared with healthy controls (HC), and increased more significantly in patients with ILD (RA-ILD) than patients without ILD (RA-nonILD). In both RA-ILD and RA-nonILD patients, serum level of IL-11 was higher in the active-disease group than that in the target-achieved group. Pearson correlation analysis confirmed that IL-11 was positively correlated with DAS28. No significant correlation was found between serum level of IL-11 and ACPA or RF. IL-11 was positively correlated with ESR and CRP levels and PLT count in RA patients. CONCLUSIONS: IL-11 was found to be involved in the development of arthritis and ILD in RA patients, and might constitute a potential target for the treatment of RA-ILD.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Enfermedades Pulmonares Intersticiales Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Exp Rheumatol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Enfermedades Pulmonares Intersticiales Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Exp Rheumatol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Italia