Metabolic Modeling Combined With Machine Learning Integrates Longitudinal Data and Identifies the Origin of LXR-Induced Hepatic Steatosis.

van Riel, Natal A W; Tiemann, Christian A; Hilbers, Peter A J; Groen, Albert K

van Riel, Natal A W; Tiemann, Christian A; Hilbers, Peter A J; Groen, Albert K.

Afiliación

van Riel NAW; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
Tiemann CA; Department of Vascular Medicine, Amsterdam UMC, Amsterdam, Netherlands.
Hilbers PAJ; Maastricht Centre for Systems Biology, Maastricht University, Maastricht, Netherlands.
Groen AK; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.

Front Bioeng Biotechnol ; 8: 536957, 2020.

Article en En | MEDLINE | ID: mdl-33665185

Palabras clave

LXR agonist; cholesterol; longitudinal trajectory modeling; machine learning; mechanistic modeling; regularization; systems biology; uncertainty quantification

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Bioeng Biotechnol Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza

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