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The posterior parietal cortex contributes to visuomotor processing for saccades in blindsight macaques.
Kato, Rikako; Hayashi, Takuya; Onoe, Kayo; Yoshida, Masatoshi; Tsukada, Hideo; Onoe, Hirotaka; Isa, Tadashi; Ikeda, Takuro.
Afiliación
  • Kato R; Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
  • Hayashi T; Department of Neuroscience, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Onoe K; Laboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Yoshida M; Center of Molecular Imaging Science, RIKEN, Kobe, Japan.
  • Tsukada H; Laboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Onoe H; Center of Molecular Imaging Science, RIKEN, Kobe, Japan.
  • Isa T; Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
  • Ikeda T; School of Life Sciences, the Graduate University of Advanced Studies (SOKENDAI), Hayama, Japan.
Commun Biol ; 4(1): 278, 2021 03 04.
Article en En | MEDLINE | ID: mdl-33664430
Patients with damage to the primary visual cortex (V1) lose visual awareness, yet retain the ability to perform visuomotor tasks, which is called "blindsight." To understand the neural mechanisms underlying this residual visuomotor function, we studied a non-human primate model of blindsight with a unilateral lesion of V1 using various oculomotor tasks. Functional brain imaging by positron emission tomography showed a significant change after V1 lesion in saccade-related visuomotor activity in the intraparietal sulcus area in the ipsi- and contralesional posterior parietal cortex. Single unit recordings in the lateral bank of the intraparietal sulcus (lbIPS) showed visual responses to targets in the contralateral visual field on both hemispheres. Injection of muscimol into the ipsi- or contralesional lbIPSs significantly impaired saccades to targets in the V1 lesion-affected visual field, differently from previous reports in intact animals. These results indicate that the bilateral lbIPSs contribute to visuomotor function in blindsight.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Movimientos Sacádicos / Visión Ocular / Corteza Visual / Percepción Visual / Conducta Animal / Ceguera Límite: Animals Idioma: En Revista: Commun Biol Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Movimientos Sacádicos / Visión Ocular / Corteza Visual / Percepción Visual / Conducta Animal / Ceguera Límite: Animals Idioma: En Revista: Commun Biol Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido