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What is the yield of malaria reactive case detection in the Greater Mekong Sub-region? A review of published data and meta-analysis.
Deen, Jacqueline; Mukaka, Mavuto; von Seidlein, Lorenz.
Afiliación
  • Deen J; Institute of Child Health and Human Development, National Institutes of Health, University of the Philippines, 623 P. Gil St, 1000, Manila, Philippines. deen.jacqueline@gmail.com.
  • Mukaka M; Faculty of Tropical Medicine, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
  • von Seidlein L; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Malar J ; 20(1): 131, 2021 Mar 04.
Article en En | MEDLINE | ID: mdl-33663484
BACKGROUND: Reactive malaria case detection involves the screening of those in contact with index cases and is used in countries in the Greater Mekong Sub-region. The yield of reactive case detection, defined here as the percentage of positive malaria cases among potential contacts who were screened, was assessed. METHODS: A literature search was conducted on PubMed to identify studies on reactive case detection in the Greater Mekong Sub-region. Eligible published articles were reviewed and pooled estimates from the studies were calculated, by type of malaria test used. RESULTS: Eighty-five publications were retrieved, of which 8 (9.4%) eligible articles were included in the analysis. The yield from reactive case detection ranged from 0.1 to 4.2%, with higher rates from PCR testing compared with microscopy and/or rapid diagnostic test. The overall yield from microscopy and/or rapid diagnostic test was 0.56% (95% CI 0.31-0.88%), while that from PCR was 2.35% (95% CI 1.19-3.87%). The two studies comparing different target groups showed higher yield from co-workers/co-travellers, compared with household contacts. CONCLUSION: In low malaria transmission settings, the effectiveness of reactive case detection is diminishing. In the Greater Mekong Sub-region, modifying reactive case detection from household contacts to co-workers/co-travellers and from testing to presumptive treatment of targeted contacts, could increase the impact of this approach.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamizaje Masivo / Reacción en Cadena de la Polimerasa / Pruebas Diagnósticas de Rutina / Malaria / Microscopía Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies / Systematic_reviews Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Malar J Asunto de la revista: MEDICINA TROPICAL Año: 2021 Tipo del documento: Article País de afiliación: Filipinas Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamizaje Masivo / Reacción en Cadena de la Polimerasa / Pruebas Diagnósticas de Rutina / Malaria / Microscopía Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies / Systematic_reviews Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Malar J Asunto de la revista: MEDICINA TROPICAL Año: 2021 Tipo del documento: Article País de afiliación: Filipinas Pais de publicación: Reino Unido