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The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease.
Galeev, Alibek; Suwandi, Abdulhadi; Cepic, Aleksa; Basu, Meghna; Baines, John F; Grassl, Guntram A.
Afiliación
  • Galeev A; Max Planck Institute for Evolutionary Biology, Plön, Germany and Institute for Experimental Medicine, Kiel University, Kiel, Germany.
  • Suwandi A; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School and German Center for Infection Research (DZIF), Hannover, Germany.
  • Cepic A; Max Planck Institute for Evolutionary Biology, Plön, Germany and Institute for Experimental Medicine, Kiel University, Kiel, Germany.
  • Basu M; Max Planck Institute for Evolutionary Biology, Plön, Germany and Institute for Experimental Medicine, Kiel University, Kiel, Germany.
  • Baines JF; Max Planck Institute for Evolutionary Biology, Plön, Germany and Institute for Experimental Medicine, Kiel University, Kiel, Germany. Electronic address: baines@evolbio.mpg.de.
  • Grassl GA; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School and German Center for Infection Research (DZIF), Hannover, Germany. Electronic address: grassl.guntram@mh-hannover.de.
Int J Med Microbiol ; 311(3): 151487, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33662872
The glycosylation profile of the gastrointestinal tract is an important factor mediating host-microbe interactions. Variation in these glycan structures is often mediated by blood group-related glycosyltransferases, and can lead to wide-ranging differences in susceptibility to both infectious- as well as chronic disease. In this review, we focus on the interplay between host glycosylation, the intestinal microbiota and susceptibility to gastrointestinal pathogens based on studies of two exemplary blood group-related glycosyltransferases that are conserved between mice and humans, namely FUT2 and B4GALNT2. We highlight that differences in susceptibility can arise due to both changes in direct interactions, such as bacterial adhesion, as well as indirect effects mediated by the intestinal microbiota. Although a large body of experimental work exists for direct interactions between host and pathogen, determining the more complex and variable mechanisms underlying three-way interactions involving the intestinal microbiota will be the subject of much-needed future research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos de Grupos Sanguíneos / Enfermedades Transmisibles / N-Acetilgalactosaminiltransferasas / Microbioma Gastrointestinal / Fucosiltransferasas Límite: Animals / Humans Idioma: En Revista: Int J Med Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos de Grupos Sanguíneos / Enfermedades Transmisibles / N-Acetilgalactosaminiltransferasas / Microbioma Gastrointestinal / Fucosiltransferasas Límite: Animals / Humans Idioma: En Revista: Int J Med Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania