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Diversity, molecular mechanisms and structure-activity relationships of marine protease inhibitors-A review.
Rauf, Abdur; Khalil, Anees Ahmed; Olatunde, Ahmed; Khan, Muneeb; Anwar, Sirajudheen; Alafnan, Ahmed; Rengasamy, Kannan Rr.
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  • Rauf A; Department of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan.
  • Khalil AA; University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Pakistan.
  • Olatunde A; Department of Biochemistry, Abubakar Tafawa Balewa University, Bauchi, Nigeria.
  • Khan M; Department of Human Nutrition and Dietetics, Riphah College of Rehabilitation and Allied Health Sciences, Riphah International University, Lahore, Pakistan.
  • Anwar S; Department of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.
  • Alafnan A; Department of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.
  • Rengasamy KR; Indigenous Knowledge Systems Centre, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X2046, Mmabatho 2745, South Africa. Electronic address: Rengasamy@iceir.net.
Pharmacol Res ; 166: 105521, 2021 04.
Article en En | MEDLINE | ID: mdl-33662574
Marine habitats are well-known for their diverse life forms that are potential sources of novel bioactive compounds. Evidence from existing studies suggests that these compounds contribute significantly to the field of pharmaceuticals, nutraceuticals, and cosmeceuticals. The isolation of natural compounds from a marine environment with protease inhibitory activity has gained importance due to drug discovery potential. Despite the increasing research endeavours focusing on protease inhibitors' design and characterization, many of these compounds have failed to reach final phases of clinical trials. As a result, the search for new sources for the development of protease inhibitors remains pertinent. This review focuses on the diverse marine protease inhibitors and their structure-activity relationships. Furthermore, the potential of marine protease inhibitors in drug discovery and molecular mechanism inhibitor binding are critically discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Países Bajos