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Biomolecular Condensates: Sequence Determinants of Phase Separation, Microstructural Organization, Enzymatic Activity, and Material Properties.
Schuster, Benjamin S; Regy, Roshan Mammen; Dolan, Elliott M; Kanchi Ranganath, Aishwarya; Jovic, Nina; Khare, Sagar D; Shi, Zheng; Mittal, Jeetain.
Afiliación
  • Schuster BS; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, New Jersey 08854, United States.
  • Regy RM; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, Pennsylvania 18015, United States.
  • Dolan EM; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.
  • Kanchi Ranganath A; Institute for Quantitative Biomedicine, Rutgers University, Piscataway, New Jersey 08854, United States.
  • Jovic N; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, New Jersey 08854, United States.
  • Khare SD; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, Pennsylvania 18015, United States.
  • Shi Z; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.
  • Mittal J; Institute for Quantitative Biomedicine, Rutgers University, Piscataway, New Jersey 08854, United States.
J Phys Chem B ; 125(14): 3441-3451, 2021 04 15.
Article en En | MEDLINE | ID: mdl-33661634
This perspective article highlights recent progress and emerging challenges in understanding the formation and function of membraneless organelles (MLOs). A long-term goal in the MLO field is to identify the sequence-encoded rules that dictate the formation of compositionally controlled biomolecular condensates, which cells utilize to perform a wide variety of functions. The molecular organization of the different components within a condensate can vary significantly, ranging from a homogeneous mixture to core-shell droplet structures. We provide many examples to highlight the richness of the observed behavior and potential research directions for improving our mechanistic understanding. The tunable environment within condensates can, in principle, alter enzymatic activity significantly. We examine recent examples where this was demonstrated, including applications in synthetic biology. An important question about MLOs is the role of liquid-like material properties in biological function. We discuss the need for improved quantitative characterization tools and the development of sequence-structure-dynamics relationships.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Orgánulos Idioma: En Revista: J Phys Chem B Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Orgánulos Idioma: En Revista: J Phys Chem B Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos