A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in Clostridioides difficile 630&#916;<i>erm</i>.

Troitzsch, Daniel; Zhang, Hao; Dittmann, Silvia; Düsterhöft, Dorothee; Möller, Timon Alexander; Michel, Annika-Marisa; Jänsch, Lothar; Riedel, Katharina; Borrero-de Acuña, José Manuel; Jahn, Dieter; Sievers, Susanne

A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in Clostridioides difficile 630Δerm.

Troitzsch, Daniel; Zhang, Hao; Dittmann, Silvia; Düsterhöft, Dorothee; Möller, Timon Alexander; Michel, Annika-Marisa; Jänsch, Lothar; Riedel, Katharina; Borrero-de Acuña, José Manuel; Jahn, Dieter; Sievers, Susanne.

Afiliación

Troitzsch D; Department of Microbial Physiology and Molecular Biology, Institute of Microbiology, University of Greifswald, Greifswald, Germany.
Zhang H; Institute of Microbiology, Technical University of Braunschweig, Braunschweig, Germany.
Dittmann S; Department of Microbial Physiology and Molecular Biology, Institute of Microbiology, University of Greifswald, Greifswald, Germany.
Düsterhöft D; Department of Microbial Physiology and Molecular Biology, Institute of Microbiology, University of Greifswald, Greifswald, Germany.
Möller TA; Department of Microbial Physiology and Molecular Biology, Institute of Microbiology, University of Greifswald, Greifswald, Germany.
Michel AM; Institute of Microbiology, Technical University of Braunschweig, Braunschweig, Germany.
Jänsch L; Braunschweig Integrated Centre of Systems Biology (BRICS), Technical University of Braunschweig, Braunschweig, Germany.
Riedel K; Helmholtz Center for Infection Research, Braunschweig, Germany.
Borrero-de Acuña JM; Department of Microbial Physiology and Molecular Biology, Institute of Microbiology, University of Greifswald, Greifswald, Germany.
Jahn D; Institute of Microbiology, Technical University of Braunschweig, Braunschweig, Germany.
Sievers S; Braunschweig Integrated Centre of Systems Biology (BRICS), Technical University of Braunschweig, Braunschweig, Germany.

mSphere ; 6(2)2021 03 03.

Article en En | MEDLINE | ID: mdl-33658275

Asunto(s)

Clostridioides difficile/genética; Estrés Oxidativo/genética; Mutación Puntual; Proteínas Represoras/genética; Factores de Transcripción/genética; ADN Bacteriano/genética; Regulación Bacteriana de la Expresión Génica; Virulencia/genética

Palabras clave

Clostridioides difficile; DNA binding; PerR; SNP; constitutive expression; oxidative stress response; rubrerythrin; single nucleotide polymorphism; transcriptional repressor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Factores de Transcripción / Clostridioides difficile / Mutación Puntual / Estrés Oxidativo Tipo de estudio: Prognostic_studies Idioma: En Revista: MSphere Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

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