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Sodium/glucose Co-Transporter 2 Inhibitor, Empagliflozin, Alleviated Transient Expression of SGLT2 after Myocardial Infarction.
Lee, Soo Yong; Lee, Tae Wook; Park, Gyu Tae; Kim, Jae Ho; Lee, Hyun Chae; Han, Jung Hwa; Yoon, Aeseon; Yoon, Dahye; Kim, Shukmann; Jung, Soon Myung; Choi, Jin Hee; Chon, Min Ku; Lee, Sang Hyun; Hwang, Ki Won; Kim, Jeongsu; Park, Yong Hyun; Kim, June Hong; Chun, Kook Jin; Hur, Jin.
Afiliación
  • Lee SY; Division of Cardiology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • Lee TW; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • Park GT; Department of Physiology, School of Medicine, Pusan National University, Yangsan, Korea.
  • Kim JH; Department of Physiology, School of Medicine, Pusan National University, Yangsan, Korea.
  • Lee HC; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • Han JH; Department of Physiology, School of Medicine, Pusan National University, Yangsan, Korea.
  • Yoon A; Department of Convergence Medicine, Pusan National University School of Medicine, Yangsan, Korea.
  • Yoon D; Department of Convergence Medicine, Pusan National University School of Medicine, Yangsan, Korea.
  • Kim S; PNU GRAND Convergence Medical Science Education Research Center, Pusan National University School of Medicine, Yangsan, Korea.
  • Jung SM; Department of Convergence Medicine, Pusan National University School of Medicine, Yangsan, Korea.
  • Choi JH; PNU GRAND Convergence Medical Science Education Research Center, Pusan National University School of Medicine, Yangsan, Korea.
  • Chon MK; Department of Chemistry, Center for Proteome Biophysics and Chemistry Institute for Functional Materials, Pusan National University, Busan, Korea.
  • Lee SH; Department of Chemistry, Center for Proteome Biophysics and Chemistry Institute for Functional Materials, Pusan National University, Busan, Korea.
  • Hwang KW; Division of Cardiology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • Kim J; Division of Cardiology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • Park YH; Division of Cardiology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • Kim JH; Division of Cardiology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • Chun KJ; Division of Cardiology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • Hur J; Division of Cardiology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
Korean Circ J ; 51(3): 251-262, 2021 Mar.
Article en En | MEDLINE | ID: mdl-33655725
BACKGROUND AND OBJECTIVES: Large clinical studies of sodium/glucose cotransporter 2 (SGLT2) inhibitors have shown a significant beneficial effect on heart failure-associated hospitalization and cardiovascular events. As SGLT2 is known to be absent in heart cells, improved cardiovascular outcomes are thought to be accounted for by the indirect effects of the drug. We sought to confirm whether such benefits were mediated through SGLT2 expressed in the heart using myocardial infarction (MI) model. METHODS: Mice pre-treated with empagliflozin (EMPA), an SGLT2 inhibitor, showed a significantly reduced infarct size compared with the vehicle group three days post-MI. Interestingly, we confirmed SGLT2 localized in the infarct zone. The sequential changes of SGLT2 expression after MI were also evaluated. RESULTS: One day after MI, SGLT2 transiently appeared in the ischemic areas in the vehicle group and increased until 72 hours. The appearance of SGLT2 was delayed and less in amount compared with the vehicle group. Additionally, there was a significant difference in metabolites, including glucose and amino acids in the ¹H nuclear magnetic resonance analysis between groups. CONCLUSIONS: Our work demonstrates that SGLT2 is transiently expressed in heart tissue early after MI and EMPA may directly operate on SGLT2 to facilitate metabolic substrates shifts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Korean Circ J Año: 2021 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Korean Circ J Año: 2021 Tipo del documento: Article Pais de publicación: Corea del Sur