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Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals.
Baek, Su-Min; Lee, Seoung-Woo; Kim, Tae-Un; Choi, Seong-Kyoon; Yun, Sungho; Lee, Won-Jae; Han, Se-Hyeon; Hong, Il-Hwa; Park, Sang-Joon; Kim, Tae-Hwan; Jeong, Kyu-Shik; Park, Jin-Kyu.
Afiliación
  • Baek SM; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
  • Lee SW; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
  • Kim TU; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
  • Choi SK; Core Protein Resources Center, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
  • Yun S; College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
  • Lee WJ; College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
  • Han SH; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
  • Hong IH; Department of News Team, Seoul Broadcasting Station (SBS), Seoul 07574, Korea.
  • Park SJ; Department of Veterinary Pathology, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea.
  • Kim TH; College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
  • Jeong KS; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
  • Park JK; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
Int J Mol Sci ; 22(5)2021 Feb 26.
Article en En | MEDLINE | ID: mdl-33652881
Senescence marker protein 30 (SMP30) is a cell survival factor playing an important role in vitamin C synthesis and antiapoptosis. Moreover, its cytoprotective role suggests a possibility to be related to cancer cell survival. Mammary carcinoma is a common cancer in both humans and animals. Because of its histopathological diversity, especially in the early stage, histopathological diagnosis may be complicated; therefore, a diagnostic marker is helpful for confirmation. The present study analyzed the expression pattern of SMP30 in mammary carcinoma in humans, dogs, and cats. Immunohistochemistry, immunofluorescence, and western blot analysis were used to investigate SMP30 expression patterns. The expression was specifically observed in neoplastic glandular epithelial cells. The expression increased with the malignancy of glandular epithelial cells with a highly proliferative status. However, SMP30 expression was low in normal mammary gland tissues or well-differentiated adenoma tissues. The patterns were consistently reproduced in canine primary mammary carcinoma cells and MCF-7 and MDA-MB-231 human carcinoma cell lines. This study provides useful information to understand SMP30 expression in various stages of mammary carcinoma and to suggest its utility as a pan-species diagnostic marker, thereby helping to establish strategies for diagnosing mammary carcinoma in several species.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas de Unión al Calcio / Enfermedades de los Gatos / Neoplasias Mamarias Animales / Péptidos y Proteínas de Señalización Intracelular / Enfermedades de los Perros Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas de Unión al Calcio / Enfermedades de los Gatos / Neoplasias Mamarias Animales / Péptidos y Proteínas de Señalización Intracelular / Enfermedades de los Perros Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article Pais de publicación: Suiza