Effects of aminopeptidase inhibitors actinonin and amastatin on chemotactic and phagocytic responses of human neutrophils.

Matsuda, N; Katsuragi, Y; Saiga, Y; Tanaka, T; Nakamura, M

Matsuda, N; Katsuragi, Y; Saiga, Y; Tanaka, T; Nakamura, M.

Afiliación

Matsuda N; Biochemical Research Laboratory, Sunstar Inc., Osaka, Japan.

Biochem Int ; 16(2): 383-90, 1988 Feb.

Article en En | MEDLINE | ID: mdl-3365269

RESUMEN

Actinonin and amastatin are low-molecular-weight inhibitors of aminopeptidases associated with cell surfaces. The purpose of this study was to determine their effects on human neutrophil functions such as chemotaxis and phagocytosis. Both actinonin and amastatin enhanced chemotaxis to the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine. On the other hand, the effects of both agents on neutrophil phagocytosis were varied. Bacterial attachment to neutrophils was slightly affected by these agents. However, actinonin enhanced the internalization of bacteria by neutrophils. Neutrophil leucine aminopeptidase activity was also determined and was found to be weakly inhibited by these agents.

Asunto(s)

Antibacterianos/farmacología; Quimiotaxis/efectos de los fármacos; Neutrófilos/efectos de los fármacos; Péptidos; Fagocitosis/efectos de los fármacos; Humanos; Ácidos Hidroxámicos/farmacología; Técnicas In Vitro; Oligopéptidos/farmacología; Análisis de Regresión

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Fagocitosis / Quimiotaxis / Antibacterianos / Neutrófilos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Biochem Int Año: 1988 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia

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