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Synthesis and cytotoxic evaluation of novel hybrid estrane heterocycles as chemotherapeutic anti-cancer agents.
Nada, Doaa S; Elkady, Dina S; Elsayed, Ghada H; A-H Abdel-Rahman, Adel; Elmegeed, Gamal A.
Afiliación
  • Nada DS; Department of Chemistry, Faculty of Science, Menofia University, Shebin El-Koam, Egypt.
  • Elkady DS; Hormones Department, National Research Centre, 12622 Dokki, Giza, Egypt.
  • Elsayed GH; Hormones Department, National Research Centre, 12622 Dokki, Giza, Egypt. Electronic address: ghadanrc@yahoo.com.
  • A-H Abdel-Rahman A; Department of Chemistry, Faculty of Science, Menofia University, Shebin El-Koam, Egypt.
  • Elmegeed GA; Hormones Department, National Research Centre, 12622 Dokki, Giza, Egypt.
Steroids ; 169: 108813, 2021 05.
Article en En | MEDLINE | ID: mdl-33652007
New synthesized hybrid steroidal heterocyclic compounds have received a lot of attention in view of their biological activities as anticancer agents. In this study, a novel class of hybrid estrane heterocyclic compounds were synthesized and evaluated by analytical and spectral data which proved the validity of these derivatives. The cytotoxicity of synthesized compounds 2a, 2b, 2c, 3b, 8, 10a, 10b, 13, 14, 16a and 19 against three human cell lines: breast cancer cells (MCF-7), prostate cancer cells (PC3), and liver cancer cells (HepG2) has been tested using MTT assay. Compounds 10a, 10b, 2c, and 14 revealed more inhibitory influence on MCF7, PC3 and HepG2 growth than the reference drug doxorubicin (Dox) after 24 h incubation. Noteworthy, the tested compounds 10a, 10b, 2c, and 14 exhibited the most pronounced effect in this respect. The results were confirmed by morphology study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antineoplásicos Límite: Humans Idioma: En Revista: Steroids Año: 2021 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antineoplásicos Límite: Humans Idioma: En Revista: Steroids Año: 2021 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos