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Endogenous anandamide and self-reported pain are significantly reduced after a 2-week multimodal treatment with and without radon therapy in patients with knee osteoarthritis: a pilot study.
Gaisberger, M; Fuchs, J; Riedl, M; Edtinger, S; Reischl, R; Grasmann, G; Hölzl, B; Landauer, F; Dobias, H; Eckstein, F; Offenbächer, M; Ritter, M; Winklmayr, M.
Afiliación
  • Gaisberger M; Institute of Physiology and Pathophysiology, Paracelsus Medical University, Strubergasse 21, A-5020, Salzburg, Austria. martin.gaisberger@pmu.ac.at.
  • Fuchs J; Gastein Research Institute, Paracelsus Medical University, Salzburg, Austria. martin.gaisberger@pmu.ac.at.
  • Riedl M; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Paracelsus Medical University, Salzburg, Austria. martin.gaisberger@pmu.ac.at.
  • Edtinger S; Institute of Physiology and Pathophysiology, Paracelsus Medical University, Strubergasse 21, A-5020, Salzburg, Austria.
  • Reischl R; Gastein Research Institute, Paracelsus Medical University, Salzburg, Austria.
  • Grasmann G; Dept. of Orthopaedics and Traumatology, Paracelsus Medical University, Salzburg, Austria.
  • Hölzl B; Department of Physical Medicine and Rehabilitation, Kardinal Schwarzenberg Klinikum, Schwarzach im Pongau, Austria.
  • Landauer F; Bioanalytical Research Labs, Department of Biosciences, University of Salzburg, Salzburg, Austria.
  • Dobias H; Bioanalytical Research Labs, Department of Biosciences, University of Salzburg, Salzburg, Austria.
  • Eckstein F; Department of Internal Med., Landesklinik St. Veit im Pongau, SALK, Paracelsus Med. Univ., Salzburg, Austria.
  • Offenbächer M; Dept. of Orthopaedics and Traumatology, Paracelsus Medical University, Salzburg, Austria.
  • Ritter M; Institute of Physiology and Pathophysiology, Paracelsus Medical University, Strubergasse 21, A-5020, Salzburg, Austria.
  • Winklmayr M; Gastein Research Institute, Paracelsus Medical University, Salzburg, Austria.
Int J Biometeorol ; 65(7): 1151-1160, 2021 Jul.
Article en En | MEDLINE | ID: mdl-33649972
Multimodal therapies comprising spa applications are widely used as non-pharmaceutical treatment options for musculoskeletal diseases. The purpose of this randomized, controlled, open pilot study was to elucidate the involvement of the endocannabinoid system in a multimodal therapy approach. Twenty-five elderly patients with knee osteoarthritis (OA) received a 2-week spa therapy with or without combination of low-dose radon therapy in the Bad Gastein radon gallery. A 10-point numerical rating scale (pain in motion and at rest), WOMAC questionnaire, and the EuroQol-5D (EQ-5D) questionnaire were recorded at baseline, and during treatment period at weeks one and two, and at 3-month and 6-month follow-ups. Plasma levels of the endocannabinoid anandamide (AEA) were determined at baseline and at 2 weeks, and serum levels of several cartilage metabolism markers at all five time-points. A significant and sustained reduction of self-reported knee pain was observed in the study population, but no further significant effect of the additional radon therapy up and above base therapy. This pain reduction was accompanied by a significant reduction of AEA plasma levels during treatment in both groups. No significant differences were seen in serum marker concentrations between the groups treated with or without radon, but a small reduction of serum cartilage degradation markers was observed during treatment in both groups. This is the first study investigating AEA levels in the context of a non-pharmacological OA treatment. Since the endocannabinoid system represents a potential target for the development of new therapeutics, further studies will have to elucidate its involvement in OA pain.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radón / Osteoartritis de la Rodilla Tipo de estudio: Clinical_trials Límite: Aged / Humans Idioma: En Revista: Int J Biometeorol Año: 2021 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radón / Osteoartritis de la Rodilla Tipo de estudio: Clinical_trials Límite: Aged / Humans Idioma: En Revista: Int J Biometeorol Año: 2021 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos