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S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates.
Liang, Joshua G; Su, Danmei; Song, Tian-Zhang; Zeng, Yilan; Huang, Weijin; Wu, Jinhua; Xu, Rong; Luo, Peiwen; Yang, Xiaofang; Zhang, Xiaodong; Luo, Shuangru; Liang, Ying; Li, Xinglin; Huang, Jiaju; Wang, Qiang; Huang, Xueqin; Xu, Qingsong; Luo, Mei; Huang, Anliang; Luo, Dongxia; Zhao, Chenyan; Yang, Fan; Han, Jian-Bao; Zheng, Yong-Tang; Liang, Peng.
Afiliación
  • Liang JG; Clover Biopharmaceuticals, Chengdu, China.
  • Su D; Clover Biopharmaceuticals, Chengdu, China.
  • Song TZ; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
  • Zeng Y; Public Health Clinical Center of Chengdu, Chengdu, China.
  • Huang W; Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, China.
  • Wu J; Clover Biopharmaceuticals, Chengdu, China.
  • Xu R; Clover Biopharmaceuticals, Chengdu, China.
  • Luo P; Clover Biopharmaceuticals, Chengdu, China.
  • Yang X; Clover Biopharmaceuticals, Chengdu, China.
  • Zhang X; Clover Biopharmaceuticals, Chengdu, China.
  • Luo S; Clover Biopharmaceuticals, Chengdu, China.
  • Liang Y; Clover Biopharmaceuticals, Chengdu, China.
  • Li X; Clover Biopharmaceuticals, Chengdu, China.
  • Huang J; Clover Biopharmaceuticals, Chengdu, China.
  • Wang Q; Clover Biopharmaceuticals, Chengdu, China.
  • Huang X; Clover Biopharmaceuticals, Chengdu, China.
  • Xu Q; Clover Biopharmaceuticals, Chengdu, China.
  • Luo M; Public Health Clinical Center of Chengdu, Chengdu, China.
  • Huang A; Department of Pathology, Chengdu Fifth People's Hospital, Chengdu, China.
  • Luo D; Public Health Clinical Center of Chengdu, Chengdu, China.
  • Zhao C; Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, China.
  • Yang F; Department of Pathology, Chengdu Fifth People's Hospital, Chengdu, China.
  • Han JB; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
  • Zheng YT; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
  • Liang P; Clover Biopharmaceuticals, Chengdu, China. liang.peng@cloverbiopharma.com.
Nat Commun ; 12(1): 1346, 2021 03 01.
Article en En | MEDLINE | ID: mdl-33649323
SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Immunization of S-Trimer with either AS03 (oil-in-water emulsion) or CpG 1018 (TLR9 agonist) plus alum adjuvants induced high-level of neutralizing antibodies and Th1-biased cellular immune responses in animal models. Moreover, rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls, based on clinical observations and reduction of viral loads in lungs. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido