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Atrial fibrillation risk in patients suffering from type I diabetes mellitus. A review of clinical and experimental evidence.
Vrachatis, Dimitrios A; Papathanasiou, Konstantinos A; Kossyvakis, Charalampos; Giotaki, Sotiria G; Raisakis, Konstantinos; Iliodromitis, Konstantinos E; Reimers, Bernhard; Stefanini, Giulio G; Cleman, Michael; Sianos, George; Lansky, Alexandra; Deftereos, Spyridon G; Giannopoulos, Georgios.
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  • Vrachatis DA; Humanitas Clinical and Research Center IRCCS, Milan, Italy; National and Kapodistrian University of Athens, Athens, Greece.
  • Papathanasiou KA; National and Kapodistrian University of Athens, Athens, Greece.
  • Kossyvakis C; General Hospital of Athens "G.Gennimatas", Athens, Greece.
  • Giotaki SG; National and Kapodistrian University of Athens, Athens, Greece.
  • Raisakis K; General Hospital of Athens "G.Gennimatas", Athens, Greece.
  • Iliodromitis KE; Evangelisches Krankenhaus Hagen-Haspe, Clinic for Cardiology and Electrophysiology, Germany.
  • Reimers B; Humanitas Clinical and Research Center IRCCS, Milan, Italy.
  • Stefanini GG; Humanitas Clinical and Research Center IRCCS, Milan, Italy.
  • Cleman M; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
  • Sianos G; Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Lansky A; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
  • Deftereos SG; National and Kapodistrian University of Athens, Athens, Greece. Electronic address: spdeftereos@gmail.com.
  • Giannopoulos G; General Hospital of Athens "G.Gennimatas", Athens, Greece.
Diabetes Res Clin Pract ; 174: 108724, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33647332
Atrial fibrillation (AF) and diabetes mellitus (DM) are commonly encountered in clinical practice. Although, the long term macrovascular and microvascular sequela of DM are well validated, the association between the less prevalent type 1 DM (T1DM) and atrial arrhythmogenesis is poorly understood. In the present review we highlight the current experimental and clinical data addressing this complex interaction. Animal studies support that T1DM, characterized by insulin deficiency and glycemic variability, impairs phosphatidylinositol 3­kinase (PI3K)/protein kinase B signaling pathway. This pathway holds a central role in atrial electrical and structural remodeling responsible for arrhythmia initiation and maintenance. The molecular ''footprint'' of T1DM in atrial myocytes seems to involve a state of increased oxidative stress, impaired glucose transportation, ionic channel dysregulation and eventually fibrosis. On the contrary only a few clinical studies have examined the role of T1DM as an independent risk factor for AF development, and are discussed here. Further research is needed to solidify the real magnitude of this association and to investigate the clinical implications of PI3K molecular signaling pathway in atrial fibrillation management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Diabetes Mellitus Tipo 1 Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Diabetes Res Clin Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Diabetes Mellitus Tipo 1 Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Diabetes Res Clin Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Irlanda