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The effect of platelet-rich plasma-fibrin glue dressing in combination with oral vitamin E and C for treatment of non-healing diabetic foot ulcers: a randomized, double-blind, parallel-group, clinical trial.
Yarahmadi, Amir; Saeed Modaghegh, Mohammad-Hadi; Mostafavi-Pour, Zohreh; Azarpira, Negar; Mousavian, Alireza; Bonakdaran, Shokoufeh; Jarahi, Lida; Samadi, Alireza; Peimani, Meghdad; Hamidi Alamdari, Daryoush.
Afiliación
  • Yarahmadi A; Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Saeed Modaghegh MH; Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mostafavi-Pour Z; Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Azarpira N; Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Mousavian A; Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Bonakdaran S; Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Jarahi L; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Samadi A; Department of Community Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Peimani M; Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Hamidi Alamdari D; Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Expert Opin Biol Ther ; 21(5): 687-696, 2021 05.
Article en En | MEDLINE | ID: mdl-33646060
OBJECTIVE: The current study assesses the effects of platelet-rich plasma-fibrin glue (PRP-FG) dressing along with oral vitamin E and C on wound healing and biochemical markers in patients with non-healing diabetic foot ulcers (non-healing DFU). METHODS: This randomized controlled trial was performed on 25 patients with non-healing DFU. Patients were treated with PRP-FG dressing plus oral vitamin E and C (intervention group) or PRP-FG dressing plus placebo (control group) for 8 weeks. RESULTS: Eight weeks after treatment, six wounds in the intervention group and two wounds in the control group were completely closed, and also wound size significantly reduced in both intervention and control groups (p < 0.05). This reduction in wound size was significantly greater in the intervention group compared to the control group (p = 0.019). Also, a significant decrease in prooxidant-antioxidant balance (PAB) , ESR, and hs-CRP was observed in the intervention group compared to the control group (p < 0.05). CONCLUSION: Our results showed that PRP-FG dressing along with oral vitamin E and C could be used to increase wound healing in patients with non-healing DFU by enhancing the wound healing process and reducing oxidative stress. TRIAL REGISTRATION: This trial is registered at ClinicalTrials.gov (CT.gov identifier: NCT04315909).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Ascórbico / Vitamina E / Adhesivo de Tejido de Fibrina / Pie Diabético / Diabetes Mellitus / Plasma Rico en Plaquetas Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Expert Opin Biol Ther Asunto de la revista: BIOLOGIA / TERAPEUTICA Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Ascórbico / Vitamina E / Adhesivo de Tejido de Fibrina / Pie Diabético / Diabetes Mellitus / Plasma Rico en Plaquetas Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Expert Opin Biol Ther Asunto de la revista: BIOLOGIA / TERAPEUTICA Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido