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Orthogonal antibody testing for COVID-19 among healthcare workers in a non-epidemic place and time:Japan's Iwate Prefecture, May 18-31, 2020.
Nakamura, Akihiro; Sato, Ryoichi; Ando, Sanae; Oana, Natsuko; Nozaki, Eiji; Endo, Hideaki; Miyate, Yoshiharu; Soma, Jun; Miyata, Go.
Afiliación
  • Nakamura A; Department of Disaster Medicine, Iwate Prefectural Central Hospital.
  • Sato R; Clinical Laboratory, Iwate Prefectural Central Hospital.
  • Ando S; Clinical Laboratory, Iwate Prefectural Central Hospital.
  • Oana N; Clinical Laboratory, Iwate Prefectural Central Hospital.
  • Nozaki E; Clinical Laboratory, Iwate Prefectural Central Hospital.
  • Endo H; Department of Cardiology, Iwate Prefectural Central Hospital.
  • Miyate Y; Department of Infection Control and Prevention, Iwate Prefectural Central Hospital.
  • Soma J; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital.
  • Miyata G; Department of Gastroenterological Surgery, Iwate Prefectural Central Hospital.
Fukushima J Med Sci ; 67(1): 27-32, 2021 Apr 10.
Article en En | MEDLINE | ID: mdl-33642419
Of the 47 prefectures in Japan, Iwate had the fewest cases of coronavirus disease 2019 (COVID-19), with the first diagnosis officially confirmed on July 28, 2020. A baseline serological survey of COVID-19 antibodies is essential to accurately evaluate an epidemic outbreak. The primary purpose of this study was to determine pre-epidemic prevalence of COVID-19 antibodies among healthcare workers, using two laboratory-based quantitative tests. In addition, a point-of-care (POC) qualitative test, rapid, simple, and convenient for primary care clinics, was compared with the laboratory-based tests. All antibody tests were performed on serum from 1,000 healthcare workers (mean age, 40 ± 11 years) in Iwate Prefectural Central Hospital, May 29-31, 2020. A COVID-19 case was defined as showing positive results in both laboratory-based quantitative tests. None of 1,000 samples had positive results in both of the laboratory immunoassays. The POC test showed positive results in 33 of 1,000 samples (3.3%) (95% confidence interval:2.19-4.41), but no samples were simultaneously positive in both laboratory-based tests. In conclusion, COVID-19 cases were not serologically confirmed by a baseline control study of healthcare workers at our hospital in late May, 2020. Moreover, the POC qualitative test may offer no advantage in areas with very low prevalence of COVID-19, due to higher false-positive reactions compared with laboratory-based quantitative immunoassays.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Personal de Salud / Prueba Serológica para COVID-19 / SARS-CoV-2 / COVID-19 Tipo de estudio: Diagnostic_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Fukushima J Med Sci Año: 2021 Tipo del documento: Article Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Personal de Salud / Prueba Serológica para COVID-19 / SARS-CoV-2 / COVID-19 Tipo de estudio: Diagnostic_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Fukushima J Med Sci Año: 2021 Tipo del documento: Article Pais de publicación: Japón