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Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance.
Dodd, Garron T; Kim, Seung Jae; Méquinion, Mathieu; Xirouchaki, Chrysovalantou E; Brüning, Jens C; Andrews, Zane B; Tiganis, Tony.
Afiliación
  • Dodd GT; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia. garron.dodd@unimelb.edu.au tony.tiganis@monash.edu.
  • Kim SJ; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
  • Méquinion M; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
  • Xirouchaki CE; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
  • Brüning JC; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
  • Andrews ZB; Department of Physiology, Monash University, VIC 3800, Australia.
  • Tiganis T; Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Sci Adv ; 7(9)2021 02.
Article en En | MEDLINE | ID: mdl-33637536
The importance of hypothalamic insulin signaling on feeding and glucose metabolism remains unclear. We report that insulin acts on AgRP neurons to acutely decrease meal size and thereby limit postprandial glucose and insulin excursions. The promotion of insulin signaling in AgRP neurons decreased meal size without altering total caloric intake, whereas the genetic ablation of the insulin receptor had the opposite effect. The promotion of insulin signaling also decreased the intake of sucrose-sweetened water or high-fat food over standard chow, without influencing food-seeking and hedonic behaviors. The ability of heightened insulin signaling to override the hedonistic consumption of highly palatable high-fat food attenuated the development of systemic insulin resistance, without affecting body weight. Our findings define an unprecedented mechanism by which insulin acutely influences glucose metabolism. Approaches that enhance insulin signaling in AgRP neurons may provide a means for altering feeding behavior in a nutrient-dense environment to combat the metabolic syndrome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina Límite: Humans Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina Límite: Humans Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos