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A comparison of the efficacy of normal saline and Savlon solutions in periurethral cleaning to reduce catheter-associated bacteriuria: A randomized control trial.
Khahakaew, Sarin; Suwanpimolkul, Gompol; Wongkeskij, Thanittha; Punakabutra, Napawan; Suankratay, Chusana.
Afiliación
  • Khahakaew S; Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: s.khahakaew@gmail.com.
  • Suwanpimolkul G; Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
  • Wongkeskij T; Department of Microbiology, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
  • Punakabutra N; Department of Microbiology, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
  • Suankratay C; Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Int J Infect Dis ; 105: 702-708, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33636356
OBJECTIVE: Catheter-associated urinary tract infection (CAUTI) is a common nosocomial infection. However, there has been no randomized control trial (RCT) comparing the efficacy of periurethral cleaning solutions for reducing CAUTI. This study aimed to compare the efficacy of normal saline solution (NSS) and Savlon solution. METHODS: A non-inferiority cross-over RCT was conducted to compare the 2 solutions by the incidence of significant bacteriuria (SB) on day 5 after Foley catheterization. Patients admitted to a tertiary referral hospital from June 2018 to August 2019 participated in the study. The acceptable prespecified non-inferiority margin was 10%. RESULTS: There were 265 and 275 patients in the NSS and Savlon groups, respectively. The incidence of CAUTI was 2.65/1000 catheter-days, and the median duration of catheterization was 5 days (IQR 4, 7). There was no significant difference between the incidence of SB in the NSS and Savlon groups, as indicated by the adjusted difference of 0.6 (95% CI: -3.1-4.2). CONCLUSION: This study was the first RCT in patients from multiple hospital units to compare the efficacy of the 2 solutions in the periurethral cleaning process. The study demonstrated non-inferiority of NSS to Savlon solution. THAI CLINICAL TRIALS REGISTRY STUDY ID: TCTR20180518001.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacteriuria / Infecciones Urinarias / Compuestos de Cetrimonio / Clorhexidina / Infecciones Relacionadas con Catéteres / Solución Salina / Antiinfecciosos Tipo de estudio: Clinical_trials / Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2021 Tipo del documento: Article Pais de publicación: Canadá
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacteriuria / Infecciones Urinarias / Compuestos de Cetrimonio / Clorhexidina / Infecciones Relacionadas con Catéteres / Solución Salina / Antiinfecciosos Tipo de estudio: Clinical_trials / Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2021 Tipo del documento: Article Pais de publicación: Canadá