Your browser doesn't support javascript.
loading
Airspace Dimension Assessment (AiDA) by inhaled nanoparticles: benchmarking with hyperpolarised 129Xe diffusion-weighted lung MRI.
Petersson-Sjögren, Madeleine; Chan, Ho-Fung; Collier, Guilhem J; Norquay, Graham; Olsson, Lars E; Wollmer, Per; Löndahl, Jakob; Wild, Jim M.
Afiliación
  • Petersson-Sjögren M; Division of Ergonomics and Aerosol Technology, Department of Design Sciences and NanoLund, Lund University, Lund, Sweden.
  • Chan HF; POLARIS, Imaging Sciences, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.
  • Collier GJ; POLARIS, Imaging Sciences, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.
  • Norquay G; POLARIS, Imaging Sciences, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.
  • Olsson LE; Department of Translational Medicine, Medical Radiation Physics, Lund University, Malmö, Sweden.
  • Wollmer P; Department of Translational Medicine, Clinical Physiology, Lund University, Malmö, Sweden.
  • Löndahl J; Division of Ergonomics and Aerosol Technology, Department of Design Sciences and NanoLund, Lund University, Lund, Sweden. Jakob.londahl@design.lth.se.
  • Wild JM; POLARIS, Imaging Sciences, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Sci Rep ; 11(1): 4721, 2021 02 25.
Article en En | MEDLINE | ID: mdl-33633165
Enlargements of distal airspaces can indicate pathological changes in the lung, but accessible and precise techniques able to measure these regions are lacking. Airspace Dimension Assessment with inhaled nanoparticles (AiDA) is a new method developed for in vivo measurement of distal airspace dimensions. The aim of this study was to benchmark the AiDA method against quantitative measurements of distal airspaces from hyperpolarised 129Xe diffusion-weighted (DW)-lung magnetic resonance imaging (MRI). AiDA and 129Xe DW-MRI measurements were performed in 23 healthy volunteers who spanned an age range of 23-70 years. The relationship between the 129Xe DW-MRI and AiDA metrics was tested using Spearman's rank correlation coefficient. Significant correlations were observed between AiDA distal airspace radius (rAiDA) and mean 129Xe apparent diffusion coefficient (ADC) (p < 0.005), distributed diffusivity coefficient (DDC) (p < 0.001) and distal airspace dimension (LmD) (p < 0.001). A mean bias of - 1.2 µm towards rAiDA was observed between 129Xe LmD and rAiDA, indicating that rAiDA is a measure of distal airspace dimension. The AiDA R0 intercept correlated with MRI 129Xe α (p = 0.02), a marker of distal airspace heterogeneity. This study demonstrates that AiDA has potential to characterize the distal airspace microstructures and may serve as an alternative method for clinical examination of the lungs.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Pulmón Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Pulmón Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido