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Effectiveness of enhancing cognitive reserve in children, adolescents and young adults at genetic risk for psychosis: Study protocol for a randomized controlled trial.
de la Serna, Elena; Montejo, Laura; Solé, Brisa; Castro-Fornieles, Josefina; Camprodon-Boadas, Patricia; Sugranyes, Gisela; Rosa-Justicia, Mireia; Martinez-Aran, Anabel; Vieta, Eduard; Vicent-Gil, Muriel; Serra-Blasco, Maria; Cardoner, Narcís; Torrent, Carla.
Afiliación
  • de la Serna E; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic of Barcelona 2017SGR881, Institut Clinic de Neurociències, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain.
  • Montejo L; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Barcelona Bipolar and Depressive Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain.
  • Solé B; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Barcelona Bipolar and Depressive Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain.
  • Castro-Fornieles J; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic of Barcelona 2017SGR881, Institut Clinic de Neurociències, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain. Electronic address: jcast
  • Camprodon-Boadas P; Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic of Barcelona 2017SGR881, Institut Clinic de Neurociències, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain.
  • Sugranyes G; Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic of Barcelona 2017SGR881, Institut Clinic de Neurociències, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain.
  • Rosa-Justicia M; Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic of Barcelona 2017SGR881, Institut Clinic de Neurociències, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain.
  • Martinez-Aran A; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Barcelona Bipolar and Depressive Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain.
  • Vieta E; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Barcelona Bipolar and Depressive Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain. Electronic address: evieta@clinic.cat.
  • Vicent-Gil M; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Depression and Anxiety Program, Institut d'Investigació i Innovació Parc Taulí, Universitat Autònoma de Barcelona (UAB), CIBERSAM, Hospital Universitari Parc Taulí, Sabadell, Barcelona, Spain.
  • Serra-Blasco M; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Depression and Anxiety Program, Institut d'Investigació i Innovació Parc Taulí, Universitat Autònoma de Barcelona (UAB), CIBERSAM, Hospital Universitari Parc Taulí, Sabadell, Barcelona, Spain.
  • Cardoner N; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Depression and Anxiety Program, Institut d'Investigació i Innovació Parc Taulí, Universitat Autònoma de Barcelona (UAB), CIBERSAM, Hospital Universitari Parc Taulí, Sabadell, Barcelona, Spain.
  • Torrent C; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Barcelona Bipolar and Depressive Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain.
Span J Psychiatry Ment Health ; 16(3): 184-191, 2023.
Article en En | MEDLINE | ID: mdl-33631372
BACKGROUND: Offspring of patients diagnosed with bipolar disorder and schizophrenia (Off-BDSZ) have a high genetic risk of developing a mental illness. The aim of this project is to develop and investigate the efficacy of an intervention aimed at this population, based on the concept of cognitive reserve. METHODS: This is a multicenter randomized trial with an experimental test-retest design study with control group. Two groups will be included: a community comparison group (CC) and a Off-BDSZ group. A total of 108 Off-BDSZ and 65 CC aged between 6 and 25 years will be recruited. Off-BDSZ participants will be randomized to receive either Cognitive Reserve EnhAncement ThErapy (CREATE) (n=54), or a supportive approach (n=54). The CC group will be assessed at baseline. The duration of the intervention will be 3 months, with 12 weekly group sessions. The primary outcome will be the improvement in CR measured according to change in the Cognitive Reserve Assessment Scale in Health (CRASH) and Cognitive Reserve scale for Adolescents (CORE-A). All participants will be blindly evaluated using clinical, cognitive and neuroimaging measures at baseline, at three months (after the psychological intervention), and at twelve-month follow-up after treatment completion. DISCUSSION: The results will provide insight into whether the CREATE-Offspring version may enhance cognitive reserve (CR) in child, adolescent and young adult Off-BDSZ as well as advance knowledge about changes in clinical manifestations, neuropsychological performance and brain structure and function associated with improving CR. This novel and cost-effective intervention represents an advance in the framework of preventive interventions in mental health. TRIAL REGISTRATION: Clinicaltrials.gov, NCT03722082. Registered on 26 October 2018.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Esquizofrenia / Trastorno Bipolar / Reserva Cognitiva Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Humans Idioma: En Revista: Span J Psychiatry Ment Health Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: España
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Esquizofrenia / Trastorno Bipolar / Reserva Cognitiva Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Humans Idioma: En Revista: Span J Psychiatry Ment Health Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: España