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Henoch-Schönlein Purpura Associated with Lung Cancer: When Paraneoplastic Manifestations Impede Oncological Management.
Philippe, Éloïse; Barnier, Aude; Menguy, Juliette; Robinet, Gilles; Quéré, Gilles; Couturaud, Francis; Descourt, Renaud.
Afiliación
  • Philippe É; Institut De Cancérologie, CHU Morvan, Brest 29200, France.
  • Barnier A; Service De Pneumologie, EA3878-GETBO, Université De Bretagne Occidentale, CHU Cavale Blanche, Boulevard Tanguy-Prigent, Brest 29200, France.
  • Menguy J; Service De Pneumologie, EA3878-GETBO, Université De Bretagne Occidentale, CHU Cavale Blanche, Boulevard Tanguy-Prigent, Brest 29200, France.
  • Robinet G; Service De Pneumologie, EA3878-GETBO, Université De Bretagne Occidentale, CHU Cavale Blanche, Boulevard Tanguy-Prigent, Brest 29200, France.
  • Quéré G; Institut De Cancérologie, CHU Morvan, Brest 29200, France.
  • Couturaud F; Institut De Cancérologie, CHU Morvan, Brest 29200, France.
  • Descourt R; Service De Pneumologie, EA3878-GETBO, Université De Bretagne Occidentale, CHU Cavale Blanche, Boulevard Tanguy-Prigent, Brest 29200, France.
Case Reports Immunol ; 2021: 8847017, 2021.
Article en En | MEDLINE | ID: mdl-33628542
BACKGROUND: Henoch-Schönlein purpura (HSP) is an uncommon syndrome that mostly occurs in children, in whom it is frequently triggered by infections. In contrast, HSP in adults is more frequently of neoplastic origin. Case Presentation. We report HSP associated with a locally advanced lung squamous cell carcinoma that was considered a paraneoplastic syndrome. Systemic corticosteroids were given because a kidney biopsy revealed active glomerulonephritis. Concomitant chemoradiotherapy achieved a partial response of the lung tumor. Consolidation immunotherapy (programmed death protein-1-ligand-1 (PD-L1) inhibitor) was cancelled because HSP is known to be an autoimmune vasculitis, and long-term corticosteroid therapy was pursued. CONCLUSION: Further prospective studies are needed to evaluate the effect of anti-PD-(L) 1 immunotherapies on autoimmune manifestations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Case Reports Immunol Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Egipto
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Case Reports Immunol Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Egipto