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Study of the pathophysiological mechanisms associated with the onset and course of neurodevelopmental disorders in preterm infants (the PeriSTRESS-PremTEA study): Rationale, objectives, design and sample description. / Estudio de los mecanismos fisiopatológicos asociados al inicio y curso de los trastornos del neurodesarrollo en prematuros (estudio PeriSTRESS-PremTEA): justificación, objetivos, diseño y descripción de la muestra.
Navalón, Pablo; Merchan-Naranjo, Jéssica; Ghosn, Farah; Almansa, Belén; Chafer-Pericas, Consuelo; González-Peñas, Javier; Rodríguez-Toscano, Elisa; Zeballos, Susana; Arriaga, María; Castro Castro, Pedro; Blanco Bravo, Dorotea; Vento, Máximo; Pina-Camacho, Laura; García-Blanco, Ana.
Afiliación
  • Navalón P; Neonatal Research Group, La Fe Health Research Institute, Valencia, España; Department of Psychiatry, La Fe University and Polytechnic Hospital, Valencia, España.
  • Merchan-Naranjo J; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañon, CIBERSAM, IiSGM, School of Medicine, Universidad Complutense, Madrid, España.
  • Ghosn F; Neonatal Research Group, La Fe Health Research Institute, Valencia, España.
  • Almansa B; Neonatal Research Group, La Fe Health Research Institute, Valencia, España.
  • Chafer-Pericas C; Neonatal Research Group, La Fe Health Research Institute, Valencia, España.
  • González-Peñas J; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañon, CIBERSAM, IiSGM, School of Medicine, Universidad Complutense, Madrid, España.
  • Rodríguez-Toscano E; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañon, CIBERSAM, IiSGM, School of Medicine, Universidad Complutense, Madrid, España.
  • Zeballos S; Department of Neonatology, Hospital General Universitario Gregorio Marañon, School of Medicine, Universidad Complutense, Madrid, España.
  • Arriaga M; Department of Neonatology, Hospital General Universitario Gregorio Marañon, School of Medicine, Universidad Complutense, Madrid, España.
  • Castro Castro P; Section of Neuropaediatrics,(.) Department of Paediatrics, Hospital General Universitario Gregorio Marañon, School of Medicine, Universidad Complutense, Madrid, España.
  • Blanco Bravo D; Department of Neonatology, Hospital General Universitario Gregorio Marañon, School of Medicine, Universidad Complutense, Madrid, España.
  • Vento M; Neonatal Research Group, La Fe Health Research Institute, Valencia, España.
  • Pina-Camacho L; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañon, CIBERSAM, IiSGM, School of Medicine, Universidad Complutense, Madrid, España. Electronic address: lpina@iisgm.com.
  • García-Blanco A; Neonatal Research Group, La Fe Health Research Institute, Valencia, España; Department of Personality, Assessment and Psychological Treatments, University of Valencia, España.
Rev Psiquiatr Salud Ment (Engl Ed) ; 2021 Feb 19.
Article en En, Es | MEDLINE | ID: mdl-33618030
BACKGROUND: There are few studies exploring the pathophysiological pathways that may condition differentially the emergence/course of neurodevelopmental disorders (ND) in very preterm and extremely preterm newborns (VPTN/EPTN). Furthermore, there are no established biological markers predictive of ND in this population. The aim of this study is four-fold: in two cohorts of VPTN/EPTN (i) to characterize the emergence/course of ND up to corrected-age 6 years, (ii) to identify those factors (from prenatal stages up to age 6 years) that explain the interindividual differences related to emergence/course of ND, (iii) to identify in the first hours/days of life a urinary metabolomic biomarker profile predictive of ND, and (iv) to determine longitudinally variations in DNA methylation patterns predictive of ND. METHODS: Observational, longitudinal, prospective, six-year follow-up, multicentre collaborative study. Two cohorts are being recruited: the PeriSTRESS-Valencia-cohort (n=26 VPTN, 18 EPTN, and 122 born-at-term controls), and the PremTEA-Madrid-cohort (n=49 EPTN and n=29 controls). RESULTS: We describe the rationale, objectives and design of the PeriSTRESS-PremTEA project and show a description at birth of the recruited samples. CONCLUSIONS: The PeriSTRESS-PremTEA project could help improve early identification of clinical, environmental and biological variables involved in the physiopathology of ND in VPTN/EPTN. It could also help to improve the early identification of non-invasive ND biomarkers in this population. This may allow early ND detection as well as early and personalised intervention for these children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En / Es Revista: Rev Psiquiatr Salud Ment (Engl Ed) Año: 2021 Tipo del documento: Article Pais de publicación: España
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En / Es Revista: Rev Psiquiatr Salud Ment (Engl Ed) Año: 2021 Tipo del documento: Article Pais de publicación: España