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Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study.
Delvecchio, Giuseppe; Maggioni, Eleonora; Pigoni, Alessandro; Crespo-Facorro, B; Nenadic, Igor; Benedetti, Francesco; Gaser, Christian; Sauer, Heinrich; Roiz-Santiañez, Roberto; Poletti, Sara; Rossetti, Maria G; Bellani, Marcella; Perlini, Cinzia; Ruggeri, Mirella; Diwadkar, Vaibhav A; Brambilla, Paolo.
Afiliación
  • Delvecchio G; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
  • Maggioni E; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
  • Pigoni A; MoMiLab Research Unit, IMT School for Advanced Studies Lucca, Lucca, Italy.
  • Crespo-Facorro B; Department of Psychiatry, University Hospital Virgen del Rocío, IBiS, University of Sevilla, Sevilla, Spain.
  • Nenadic I; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Santander, Spain.
  • Benedetti F; Department of Psychiatry and Psychotherapy, Philipps-University Marburg/Marburg University Hospital - UKGM, Marburg, Germany.
  • Gaser C; Division of Neuroscience, Unit of Psychiatry and Clinical Psychobiology, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Sauer H; Department of Psychiatry, University Hospital Jena, Jena, Germany.
  • Roiz-Santiañez R; Department of Psychiatry, University Hospital Jena, Jena, Germany.
  • Poletti S; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Santander, Spain.
  • Rossetti MG; Department of Psychiatry, School of Medicine, University Hospital Marqués de Valdecilla, University of Cantabria-IDIVAL, Santander, Spain.
  • Bellani M; Division of Neuroscience, Unit of Psychiatry and Clinical Psychobiology, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Perlini C; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
  • Ruggeri M; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.
  • Diwadkar VA; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.
  • Brambilla P; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Psychology, University of Verona, Verona, Italy.
Front Aging Neurosci ; 13: 622054, 2021.
Article en En | MEDLINE | ID: mdl-33613268
Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT). Three hundred and seventy three subjects underwent a 3.0 T MRI session across four European Centers. Age by sex effects on GM volumes were investigated using voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions (ROI). Females and males showed overlapping and non-overlapping patterns of GM volume changes during aging. Overlapping age-related changes emerged in bilateral frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These findings highlight the importance of accounting for sex differences in cross-sectional analyses, not only in the study of normative changes, but particularly in the context of psychiatric and neurologic disorders, wherein sex effects may be confounded with disease-related changes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Front Aging Neurosci Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Front Aging Neurosci Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza