Your browser doesn't support javascript.
loading
Progression of malaria induced pathogenicity during chloroquine therapy.
Zaid, O I; Abd Majid, R; Sidek, H M; Noor, S M; Abd Rachman-Isnadi, M F; Bello, R O; Chin, V K; Basir, R.
Afiliación
  • Zaid OI; Pharmacology Unit, Department of Pharmacy, Al Rafidain University, Al Mustansyria, Baghdad, Iraq.
  • Abd Majid R; Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor.
  • Sidek HM; School of Bioscience and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.
  • Noor SM; Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor.
  • Abd Rachman-Isnadi MF; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor.
  • Bello RO; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor.
  • Chin VK; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor.
  • Basir R; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor.
Trop Biomed ; 37(1): 29-49, 2020 Mar 01.
Article en En | MEDLINE | ID: mdl-33612716
Treatment Failure with chloroquine is one of the challenges that faced the dedicated efforts to eradicate malaria This study aims at investigating the impact of treatment failure with chloroquine on the progression of the disease-induced histo-pathogenic and immunogenic outcomes. To achieve this, Rane's protocol with modifications was applied on a model of Plasmodium berghei ANKA infected ICR mice to determine the dose response curve of chloroquine and to screen the treatment impact on the disease progression. Chloroquine was given at 1, 5, 10, 15 and 20 mg/kg once the parasitemia reached to 20-30% (the experimental initiation point). During the subsequent days, the mice were monitored for changes in the clinical signs, hematology parameters and the progress of the parasitemia until the parasitemia reached to 60-70% (the experimental termination point) or up to 10 days after chloroquine administration in case of achieving a complete eradication of the parasite. At the end, the mice were exsanguinated and their blood and organs were collected for the biochemistry and the histology study. A complete eradication of the parasite was achieved at 20 mg/kg while recrudescence was observed at the lower doses. At 1 mg/kg, the parasite growth was comparable to that of the positive control. The histo-pathogenic and immunogenic changes were stronger in the groups that experienced recrudescence (at 5 and 10 mg/kg). All in all, the study highlights the possibility of having a worsened clinical condition when chloroquine is given at its sub-therapeutic doses during malaria treatment.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloroquina / Malaria / Antimaláricos Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Trop Biomed Asunto de la revista: MEDICINA TROPICAL / PARASITOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Irak Pais de publicación: Malasia
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloroquina / Malaria / Antimaláricos Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Trop Biomed Asunto de la revista: MEDICINA TROPICAL / PARASITOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Irak Pais de publicación: Malasia