Synthesis of Substituted Anilines from Cyclohexanones Using Pd/C-Ethylene System and Its Application to Indole Synthesis.

Maeda, Katsumi; Matsubara, Ryosuke; Hayashi, Masahiko

Maeda, Katsumi; Matsubara, Ryosuke; Hayashi, Masahiko.

Afiliación

Maeda K; Department of Chemistry, Graduate School of Science, Kobe University, Kobe 657-8501, Japan.
Matsubara R; Department of Chemistry, Graduate School of Science, Kobe University, Kobe 657-8501, Japan.
Hayashi M; Department of Chemistry, Graduate School of Science, Kobe University, Kobe 657-8501, Japan.

Org Lett ; 23(5): 1530-1534, 2021 03 05.

Article en En | MEDLINE | ID: mdl-33606535

RESUMEN

The synthesis of anilines and indoles from cyclohexanones using a Pd/C-ethylene system is reported. A simple combination of NH4OAc and K2CO3 under nonaerobic conditions was found to be the most suitable to perform this reaction. Hydrogen transfer between cyclohexanone and ethylene generates the desired products. The reaction tolerates a variety of substitutions on the starting cyclohexanones.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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