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Viral Reservoir in Early-Treated Human Immunodeficiency Virus-Infected Children and Markers for Sustained Viral Suppression.
Ajibola, Gbolahan; Garcia-Broncano, Pilar; Maswabi, Kenneth; Bennett, Kara; Hughes, Michael D; Moyo, Sikhulile; Mohammed, Terrence; Jean-Philippe, Patrick; Sakoi, Maureen; Batlang, Oganne; Lockman, Shahin; Makhema, Joseph; Kuritzkes, Daniel R; Lichterfeld, Mathias; Shapiro, Roger L.
Afiliación
  • Ajibola G; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Garcia-Broncano P; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
  • Maswabi K; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Bennett K; Bennett Statistical Consulting Inc, Ballston Lake, New York, USA.
  • Hughes MD; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Moyo S; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Mohammed T; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Jean-Philippe P; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Sakoi M; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Batlang O; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Lockman S; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Makhema J; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Kuritzkes DR; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Lichterfeld M; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Shapiro RL; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Clin Infect Dis ; 73(4): e997-e1003, 2021 08 16.
Article en En | MEDLINE | ID: mdl-33605999
BACKGROUND: The impact of very early infant treatment on human immunodeficiency virus (HIV) reservoir, and markers for treatment success, require study. METHODS: The Early Infant Treatment Study (EIT) enrolled 40 children living with HIV started on antiretroviral treatment (ART) at <7 days of age, with 23 who had started treatment between 30-365 days to serve as controls. Quantitative HIV DNA was evaluated every 1-3 months in peripheral blood mononuclear cells. 84-week repeat qualitative whole blood DNA polymerase chain reaction and dual enzyme immunosorbent assay were performed. RESULTS: Median quantitative cell-associated DNA after at least 84 weeks was significantly lower among the first 27 EIT children tested than among 10 controls (40.8 vs 981.4 copies/million cells; P < .001) and correlated with pre-ART DNA. Median DNA after 84 weeks did not differ significantly by negative or positive serostatus at 84 weeks (P = .94), and appeared unaffected by periods of unsuppressed plasma RNA from 24-84 weeks (P = .70). However, negative 84-week serostatus was 67% predictive for sustained RNA suppression, and positive serostatus was 100% predictive for viremia. Loss of qualitative DNA positivity at 84 weeks was 73% predictive for sustained suppression, and persistent positivity was 77% predictive for viremia. CONCLUSIONS: Lower viral reservoir was associated with starting ART at <1 week. Negative serostatus and qualitative DNA were useful markers of sustained viral suppression from 24-84 weeks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Infecciones por VIH Tipo de estudio: Qualitative_research Límite: Child / Humans Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2021 Tipo del documento: Article País de afiliación: Botswana Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Infecciones por VIH Tipo de estudio: Qualitative_research Límite: Child / Humans Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2021 Tipo del documento: Article País de afiliación: Botswana Pais de publicación: Estados Unidos