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Structure of the parotid gland in natural infection by Leishmania infantum in Canis familiaris.
Fonseca, Clarisse Maria Barbosa; Mendonça, Tarsia Giabardo Silva; Pereira, Cristian Francisco de Carvalho; de Barros, Gabriel Martins; da Silva, Andrezza Braga Soares; Cavalcante, Maria Michele Araújo de Sousa; Cruz, Maria do Socorro Pires E; Conde Júnior, Airton Mendes.
Afiliación
  • Fonseca CMB; Master Program in Science and Health, Universidade Federal do Piauí, Campus Ministro Petrônio Portella, CEP: 64059-550, Teresina, Piauí, Brazil. Electronic address: clarissembfonseca@gmail.com.
  • Mendonça TGS; Master Program in Science and Health, Universidade Federal do Piauí, Campus Ministro Petrônio Portella, CEP: 64059-550, Teresina, Piauí, Brazil.
  • Pereira CFC; Department of Morphology, Health Sciences Center, Universidade Federal do Piauí, Campus Ministro Petrônio Portella, CEP: 64059-550, Teresina, Piauí, Brazil.
  • de Barros GM; Master Program in Science and Health, Universidade Federal do Piauí, Campus Ministro Petrônio Portella, CEP: 64059-550, Teresina, Piauí, Brazil.
  • da Silva ABS; Doctoral Program in Technologies Applied to Animals of Regional Interest, Universidade Federal do Piauí, Campus Ministro Petrônio Portella, CEP: 64059-550, Teresina, Piauí, Brazil.
  • Cavalcante MMAS; Doctoral Program in Technologies Applied to Animals of Regional Interest, Universidade Federal do Piauí, Campus Ministro Petrônio Portella, CEP: 64059-550, Teresina, Piauí, Brazil.
  • Cruz MDSPE; Department of Veterinary Morphophysiology, Center for Agricultural Sciences, Universidade Federal do Piauí, Campus Ministro Petrônio Portella, CEP: 64059-550, Teresina, Piauí, Brazil.
  • Conde Júnior AM; Master Program in Science and Health, Universidade Federal do Piauí, Campus Ministro Petrônio Portella, CEP: 64059-550, Teresina, Piauí, Brazil.
Arch Oral Biol ; 124: 105077, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33601301
OBJECTIVE: The objective of this study was to perform a histopathological, morphometric and proteomic study of the parotid gland of dogs naturally infected with Leishmania infantum treated and not treated with Allopurinol. DESIGN: Parotid glands from 14 dogs were used, divided into two groups: untreated and treated with oral allopurinol (20 mg / kg, once daily for 90 days). After adequate dissection, the organs were submitted to histopathological, histomorphometric and immunohistochemical techniques, using the monoclonal anti-ß-catenin antibody. RESULTS: Histopathological evaluation of treated and untreated groups showed acinar hypertrophy, structural disorganization of the nucleus and cytoplasm. There was an increase in the area and perimeter of the parotid acini in the experimental groups. The immunostaining of the ß-catenin protein in the membrane was severely reduced in the treated and untreated groups. CONCLUSIONS: These findings suggest that Leishmania infantum infection and treatment with Allopurinol alter the tissue structure of the parotid gland in dogs, promoting an increase in the acinar volume and a decrease in the expression of ß-catenin in cell membranes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmania infantum / Enfermedades de los Perros / Leishmaniasis Visceral Límite: Animals Idioma: En Revista: Arch Oral Biol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmania infantum / Enfermedades de los Perros / Leishmaniasis Visceral Límite: Animals Idioma: En Revista: Arch Oral Biol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido