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Antibacterial p-Terphenyl with a Rare 2,2'-Bithiazole Substructure and Related Compounds Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086.
Chang, Yimin; Che, Qian; Xing, Li; Ma, Chuanteng; Han, Yaxin; Zhu, Tianjiao; Pfeifer, Blaine A; Peng, Jixing; Zhang, Guojian; Li, Dehai.
Afiliación
  • Chang Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Che Q; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Xing L; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Ma C; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Han Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Zhu T; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Pfeifer BA; Department of Chemical and Biological Engineering, The State University of New York at Buffalo, Buffalo, New York 14260, United States.
  • Peng J; Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
  • Zhang G; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Li D; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, People's Republic of China.
J Nat Prod ; 84(4): 1226-1231, 2021 04 23.
Article en En | MEDLINE | ID: mdl-33600172
Assisted by MS/MS-based molecular networking and X-ray diffraction analysis, five new p-terphenyl derivatives, namely, nocarterphenyls D-H (1-5), were obtained and characterized from the cultures of the marine sediment-derived actinomycete Nocardiopsis sp. HDN154086. The skeleton of nocarterphenyl D (1) was defined to possess a rare 2,2'-bithiazole scaffold, naturally occurring for the first time, and nocarterphenyls E-H (2-5) are p-terphenylquinones with unusual thioether linked fatty acid methyl ester substitutions. Compound 1 showed promising activity against multiple bacteria with MIC values ranging from 1.5 to 6.2 µM, and 2 exhibited notable antibacterial activity against MRSA which surpassed the positive control ciprofloxacin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Terfenilo / Nocardiopsis / Antibacterianos País/Región como asunto: Asia Idioma: En Revista: J Nat Prod Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Terfenilo / Nocardiopsis / Antibacterianos País/Región como asunto: Asia Idioma: En Revista: J Nat Prod Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos