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Implications of Abdominal Adipose Tissue Distribution on Nonalcoholic Fatty Liver Disease and Metabolic Syndrome: A Chinese General Population Study.
Chiyanika, Chileka; Wong, Vincent Wai-Sun; Wong, Grace Lai-Hung; Chan, Henry Lik-Yuen; Hui, Steve C N; Yeung, David K W; Chu, Winnie C W.
Afiliación
  • Chiyanika C; Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China.
  • Wong VW; Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
  • Wong GL; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
  • Chan HL; Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
  • Hui SCN; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
  • Yeung DKW; Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
  • Chu WCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Clin Transl Gastroenterol ; 12(2): e00300, 2021 02 17.
Article en En | MEDLINE | ID: mdl-33600104
INTRODUCTION: Visceral adipose tissue (VAT) has been found to play a critical role in the development of metabolic syndrome and nonalcoholic fatty liver disease (NAFLD) independent of generalized obesity. METHODS: In this secondary study of prospectively acquired data, 625 participants underwent magnetic resonance spectroscopy and chemical shift fat-water separation MRI (2-point Dixon) of the liver and whole abdomen, respectively, in a 3 Tesla magnet. Whole abdominal VAT and subcutaneous adipose tissue (SAT) were extracted from the 2-point Dixon image series using an automated method. Clinical/anthropometric/blood biochemistry parameters were measured. Using region-specific body mass index, participants were classified into 3 paired subgroups (lean, overweight, and obese) and presence of NAFLD (liver fat content ≥ 5.5%). RESULTS: All relevant clinical/anthropometric/blood biochemistry characteristics and liver enzymes were statistically significant between groups (P < 0.001). NAFLD was found in 12.1%, 43.8%, and 68.3% and metabolic syndrome in 51.1%, 61.9%, and 65% of the lean, overweight, and obese, respectively. Odds ratio for metabolic syndrome and NAFLD was increased by 2.73 (95% confidence interval [CI] 2.18-3.40) and 2.53 (95% CI 2.04-3.12), respectively, for 1SD increase in VAT volume while prevalence of metabolic syndrome was increased by 2.26 (95% CI 1.83-2.79) for 1SD increase in liver fat content (%). VAT/SAT ratio in the lean with fatty liver showed the highest ratio (0.54) among all the subgroups, without a significant difference between the lean and obese with NAFLD (P = 0.127). DISCUSSION: Increased VAT volume/disproportional distribution of VAT/SAT may be vital drivers to the development of metabolic syndrome and NAFLD irrespective of body mass index category.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Metabólico / Grasa Abdominal / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Clin Transl Gastroenterol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Metabólico / Grasa Abdominal / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Clin Transl Gastroenterol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos