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Pancreatic and hepatobiliary manifestations of nonalcoholic fatty pancreatic disease: a referral multi-center experience.
Sbeit, Wisam; Greener, Tomer; Kadah, Anas; Mari, Amir; Goldin, Eran; Mahamid, Mahmud; Khoury, Tawfik.
Afiliación
  • Sbeit W; Department of Gastroenterology, Galilee Medical Center, Nahariya.
  • Greener T; Faculty of Medicine in the Galilee, Bar-Ilan University, Safed.
  • Kadah A; Faculty of Medicine, Hebrew University of Jerusalem.
  • Mari A; Department of Gastroenterology and Liver Diseases, Shaare Zedek Medical Center, Jerusalem.
  • Goldin E; Department of Gastroenterology, Galilee Medical Center, Nahariya.
  • Mahamid M; Faculty of Medicine in the Galilee, Bar-Ilan University, Safed.
  • Khoury T; Faculty of Medicine in the Galilee, Bar-Ilan University, Safed.
Eur J Gastroenterol Hepatol ; 33(1S Suppl 1): e297-e301, 2021 12 01.
Article en En | MEDLINE | ID: mdl-33600093
BACKGROUND: Nonalcoholic fatty pancreatic disease (NAFPD) is an increasingly recognized disease with accumulating evidence of associated co-morbidities. However, data linked with other pancreatic and hepatobiliary disorders are still being studied. AIMS: To investigate the association of pancreato-hepato-biliary disorders with NAFPD. METHODS: At two Israeli medical centers, a total of 569 patients were analyzed who underwent endoscopic ultrasound for hepatobiliary indications. They were divided into groups depending on the presence or absence of NAFPD. RESULTS: Seventy-eight patients (13.7%) had NAFPD (NAFPD group) vs. 491 patients (86.3%) without (non-NAFPD group). NAFPD was significantly associated with obesity [odds ratio (OR) 4.98, 95% confidence interval (CI) 3.02-8.24, P < 0.0001], hypertension (OR 2.55, 95% CI 1.57-4.15, P = 0.0002), active smoking (OR 2.02, 95% CI 1.04-3.93, P = 0.03), and hyperlipidemia (OR 2.86, 95% CI 1.58-5.18, P = 0.0005). On multivariate regression analysis: fatty liver (OR 5.49, 95% CI 2.88-10.49, P < 0.0001), main duct intraductal papillary mucinous neoplasm (M-IPMN) (OR 2.69, 95% CI 1.05-6.9, P = 0.04), and gallstones (OR 1.93, 95% CI 1.1-3.38, P = 0.02) were the most endoscopically and ultrasonographically detected diseases that significantly correlated with NAFPD. CONCLUSION: NAFPD was associated with several diseases, most importantly the premalignant M-IPMN. Further investigation for these coexisting diseases should be considered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Pancreáticas / Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Neoplasias Intraductales Pancreáticas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Pancreáticas / Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Neoplasias Intraductales Pancreáticas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido