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Delayed initiation of adjuvant chemotherapy among women with breast cancer in Addis Ababa, Ethiopia.
Gebremariam, Alem; Assefa, Mathewos; Addissie, Adamu; Worku, Alemayehu; Dereje, Nebiyu; Abreha, Aynalem; Tigeneh, Wondemagegnehu; Pace, Lydia E; Kantelhardt, Eva Johanna; Jemal, Ahmedin.
Afiliación
  • Gebremariam A; Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Tigray, Adigrat, Ethiopia. alemg25@gmail.com.
  • Assefa M; Department of Preventive Medicine, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. alemg25@gmail.com.
  • Addissie A; Radiotherapy Center, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
  • Worku A; Department of Preventive Medicine, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
  • Dereje N; Department of Preventive Medicine, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
  • Abreha A; Department of Preventive Medicine, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
  • Tigeneh W; Department of Public Health, College of Medicine and Health Sciences, Wachemo University, Hossana, Ethiopia.
  • Pace LE; Radiotherapy Center, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
  • Kantelhardt EJ; Radiotherapy Center, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
  • Jemal A; Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Breast Cancer Res Treat ; 187(3): 877-882, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33599864
PURPOSE: Chemotherapy within 90 days following surgery for non-metastatic breast cancer is the standard of care. There are no data, however, on the extent of time to initiation of chemotherapy (TTC) in Africa settings, including Ethiopia. METHODS: A total of 223 women with stage I-III breast cancer treated with surgery and adjuvant chemotherapy during 2017-2019 in Addis Ababa, Ethiopia, were included in the analysis. Based on information from medical records, we calculated TTC from date of surgery and completion of planned chemotherapy, with TTC > 90 days considered delayed and receipt of 85% of planned therapy as complete. Multivariable Poisson regression with robust variance was used to assess whether TTC > 90 days was associated with sociodemographic or clinical factors. RESULTS: The median TTC was 63 days. Chemotherapy initiation was delayed in 30% (95% CI 24.4-36.6%) of patients, with the risk significantly higher in low-income women. For example, the risk of delay in women with lowest quartile family monthly income group (US$ < 61) was 3.98 (95% CI 1.67-9.46) higher than in those women with highest quartile family income group (US$ > 194). Remarkably, adjuvant chemotherapy was completed in 95% of patients. CONCLUSIONS: A staggering one-in-three women with breast cancer in Addis Ababa, Ethiopia, delay to initiation of adjuvant chemotherapy, with the delay more common in low-income women and yet with remarkably high degree of treatment adherence. These findings underscore the need for public policy to expand health care to low-income population to improve breast cancer care and other health outcomes in the country.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Límite: Female / Humans País/Región como asunto: Africa Idioma: En Revista: Breast Cancer Res Treat Año: 2021 Tipo del documento: Article País de afiliación: Etiopia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Límite: Female / Humans País/Región como asunto: Africa Idioma: En Revista: Breast Cancer Res Treat Año: 2021 Tipo del documento: Article País de afiliación: Etiopia Pais de publicación: Países Bajos