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Control of feeding by Piezo-mediated gut mechanosensation in Drosophila.
Min, Soohong; Oh, Yangkyun; Verma, Pushpa; Whitehead, Samuel C; Yapici, Nilay; Van Vactor, David; Suh, Greg Sb; Liberles, Stephen.
Afiliación
  • Min S; Howard Hughes Medical Institute, Harvard Medical School, Department of Cell Biology, Boston, United States.
  • Oh Y; Skirball Institute, NYU School of Medicine, New York, United States.
  • Verma P; Harvard Medical School, Department of Cell Biology, Boston, United States.
  • Whitehead SC; Department of Physics, Cornell University, Ithaca, United States.
  • Yapici N; Department of Neurobiology and Behavior, Cornell University, Ithaca, United States.
  • Van Vactor D; Harvard Medical School, Department of Cell Biology, Boston, United States.
  • Suh GS; Skirball Institute, NYU School of Medicine, New York, United States.
  • Liberles S; KAIST, Department of Biological Sciences, Daejeon, Republic of Korea.
Elife ; 102021 02 18.
Article en En | MEDLINE | ID: mdl-33599608
Across animal species, meals are terminated after ingestion of large food volumes, yet underlying mechanosensory receptors have so far remained elusive. Here, we identify an essential role for Drosophila Piezo in volume-based control of meal size. We discover a rare population of fly neurons that express Piezo, innervate the anterior gut and crop (a food reservoir organ), and respond to tissue distension in a Piezo-dependent manner. Activating Piezo neurons decreases appetite, while Piezo knockout and Piezo neuron silencing cause gut bloating and increase both food consumption and body weight. These studies reveal that disrupting gut distension receptors changes feeding patterns and identify a key role for Drosophila Piezo in internal organ mechanosensation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Drosophila / Mecanotransducción Celular / Drosophila melanogaster / Canales Iónicos Límite: Animals Idioma: En Revista: Elife Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Drosophila / Mecanotransducción Celular / Drosophila melanogaster / Canales Iónicos Límite: Animals Idioma: En Revista: Elife Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido