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Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections.
Straub, Timothy J; Chou, Wen-Chi; Manson, Abigail L; Schreiber, Henry L; Walker, Bruce J; Desjardins, Christopher A; Chapman, Sinéad B; Kaspar, Kerrie L; Kahsai, Orsalem J; Traylor, Elizabeth; Dodson, Karen W; Hullar, Meredith A J; Hultgren, Scott J; Khoo, Christina; Earl, Ashlee M.
Afiliación
  • Straub TJ; Infectious Disease & Microbiome Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.
  • Chou WC; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Manson AL; Infectious Disease & Microbiome Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.
  • Schreiber HL; Infectious Disease & Microbiome Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.
  • Walker BJ; Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Desjardins CA; Center for Women's Infectious Disease Research, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Chapman SB; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
  • Kaspar KL; Infectious Disease & Microbiome Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.
  • Kahsai OJ; Infectious Disease & Microbiome Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.
  • Traylor E; Infectious Disease & Microbiome Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.
  • Dodson KW; Ocean Spray Cranberries, Lakeville-Middleboro, MA, USA.
  • Hullar MAJ; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Hultgren SJ; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Khoo C; Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Earl AM; Center for Women's Infectious Disease Research, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
BMC Microbiol ; 21(1): 53, 2021 02 18.
Article en En | MEDLINE | ID: mdl-33596852
BACKGROUND: Urinary tract infections (UTIs) affect 15 million women each year in the United States, with > 20% experiencing frequent recurrent UTIs. A recent placebo-controlled clinical trial found a 39% reduction in UTI symptoms among recurrent UTI sufferers who consumed a daily cranberry beverage for 24 weeks. Using metagenomic sequencing of stool from a subset of these trial participants, we assessed the impact of cranberry consumption on the gut microbiota, a reservoir for UTI-causing pathogens such as Escherichia coli, which causes > 80% of UTIs. RESULTS: The overall taxonomic composition, community diversity, carriage of functional pathways and gene families, and relative abundances of the vast majority of observed bacterial taxa, including E. coli, were not changed significantly by cranberry consumption. However, one unnamed Flavonifractor species (OTU41), which represented ≤1% of the overall metagenome, was significantly less abundant in cranberry consumers compared to placebo at trial completion. Given Flavonifractor's association with negative human health effects, we sought to determine OTU41 characteristic genes that may explain its differential abundance and/or relationship to key host functions. Using comparative genomic and metagenomic techniques, we identified genes in OTU41 related to transport and metabolism of various compounds, including tryptophan and cobalamin, which have been shown to play roles in host-microbe interactions. CONCLUSION: While our results indicated that cranberry juice consumption had little impact on global measures of the microbiome, we found one unnamed Flavonifractor species differed significantly between study arms. This suggests further studies are needed to assess the role of cranberry consumption and Flavonifractor in health and wellbeing in the context of recurrent UTI. TRIAL REGISTRATION: Clinical trial registration number: ClinicalTrials.gov NCT01776021 .
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Extractos Vegetales / Vaccinium macrocarpon / Microbioma Gastrointestinal Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: BMC Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Extractos Vegetales / Vaccinium macrocarpon / Microbioma Gastrointestinal Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: BMC Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido