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Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2.
Gasser, Romain; Cloutier, Marc; Prévost, Jérémie; Fink, Corby; Ducas, Éric; Ding, Shilei; Dussault, Nathalie; Landry, Patricia; Tremblay, Tony; Laforce-Lavoie, Audrey; Lewin, Antoine; Beaudoin-Bussières, Guillaume; Laumaea, Annemarie; Medjahed, Halima; Larochelle, Catherine; Richard, Jonathan; Dekaban, Gregory A; Dikeakos, Jimmy D; Bazin, Renée; Finzi, Andrés.
Afiliación
  • Gasser R; Centre de recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.
  • Cloutier M; Héma-Québec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, Canada.
  • Prévost J; Centre de recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.
  • Fink C; Biotherapeutics Research Laboratory, Robarts Research Institute, London, ON NGA 5B7, Canada; Department of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5B7, Canada.
  • Ducas É; Héma-Québec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, Canada.
  • Ding S; Centre de recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.
  • Dussault N; Héma-Québec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, Canada.
  • Landry P; Héma-Québec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, Canada.
  • Tremblay T; Héma-Québec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, Canada.
  • Laforce-Lavoie A; Héma-Québec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, Canada.
  • Lewin A; Héma-Québec, Affaires Médicales et Innovation, Montréal, QC H4R 2W7, Canada; Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
  • Beaudoin-Bussières G; Centre de recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.
  • Laumaea A; Centre de recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.
  • Medjahed H; Centre de recherche du CHUM, Montréal, QC H2X 0A9, Canada.
  • Larochelle C; Centre de recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada; Department of Neurosciences, University of Montreal, Montreal, QC H2X 0A9, Canada.
  • Richard J; Centre de recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.
  • Dekaban GA; Biotherapeutics Research Laboratory, Robarts Research Institute, London, ON NGA 5B7, Canada; Department of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5B7, Canada.
  • Dikeakos JD; Department of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5B7, Canada.
  • Bazin R; Héma-Québec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, Canada. Electronic address: renee.bazin@hema-quebec.qc.ca.
  • Finzi A; Centre de recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada. Electronic address: andres.finzi@um
Cell Rep ; 34(9): 108790, 2021 03 02.
Article en En | MEDLINE | ID: mdl-33596407
Characterization of the humoral response to SARS-CoV-2, the etiological agent of COVID-19, is essential to help control the infection. The neutralization activity of plasma from patients with COVID-19 decreases rapidly during the first weeks after recovery. However, the specific role of each immunoglobulin isotype in the overall neutralizing capacity is still not well understood. In this study, we select plasma from a cohort of convalescent patients with COVID-19 and selectively deplete immunoglobulin A, M, or G before testing the remaining neutralizing capacity of the depleted plasma. We find that depletion of immunoglobulin M is associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This observation may help design efficient antibody-based COVID-19 therapies and may also explain the increased susceptibility to SARS-CoV-2 of autoimmune patients receiving therapies that impair the production of immunoglobulin M (IgM).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina M / SARS-CoV-2 / COVID-19 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Cell Rep Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina M / SARS-CoV-2 / COVID-19 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Cell Rep Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos