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Current concepts in the pathogenesis of cryptoglandular perianal fistula.
Wlodarczyk, Marcin; Wlodarczyk, Jakub; Sobolewska-Wlodarczyk, Aleksandra; Trzcinski, Radzislaw; Dziki, Lukasz; Fichna, Jakub.
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  • Wlodarczyk M; Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland.
  • Wlodarczyk J; Department of Biochemistry, Medical University of Lodz, Lodz, Poland.
  • Sobolewska-Wlodarczyk A; Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland.
  • Trzcinski R; Department of Biochemistry, Medical University of Lodz, Lodz, Poland.
  • Dziki L; Department of Biochemistry, Medical University of Lodz, Lodz, Poland.
  • Fichna J; Department of Gastroenterology, Medical University of Lodz, Lodz, Poland.
J Int Med Res ; 49(2): 300060520986669, 2021 Feb.
Article en En | MEDLINE | ID: mdl-33595349
Cryptoglandular perianal fistula is a common benign anorectal disorder that is managed mainly with surgery. A fistula is typically defined as a pathological communication between two epithelialized surfaces. More specifically, perianal fistula manifests as an abnormal tract between the anorectal canal and the perianal skin. Perianal fistulas are often characterized by significantly decreased patient quality of life. The cryptoglandular theory of perianal fistulas suggests their development from the proctodeal glands, which originate from the intersphincteric plane and perforate the internal sphincter with their ducts. Involvement of proctodeal glands in the inflammatory process could play a primary role in the formation of cryptoglandular perianal fistula. The objective of this narrative review was to investigate the current knowledge of the pathogenesis of cryptoglandular perianal fistula with the specific aims of characterizing the potential role of proinflammatory factors responsible for the development of chronic inflammation. Further studies are crucial to improve the therapeutic management of cryptoglandular perianal fistulas.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Fístula Rectal Tipo de estudio: Etiology_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: J Int Med Res Año: 2021 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Fístula Rectal Tipo de estudio: Etiology_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: J Int Med Res Año: 2021 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido