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Systemic inflammatory status - a bridge between gestational weight gain and neonatal outcomes (STROBE-compliant article).
Rugina, Cosmin; Marginean, Cristina Oana; Melit, Lorena Elena; Hutanu, Adina; Ghiga, Dana Valentina; Modi, Viviana; Marginean, Claudiu.
Afiliación
  • Rugina C; George Emil Palade" University of Medicine.
  • Marginean CO; Department of Pediatrics, "George Emil Palade" University of Medicine.
  • Melit LE; Department of Pediatrics, "George Emil Palade" University of Medicine.
  • Hutanu A; Research Laboratory, Center for Advanced Medical and Pharmaceutical Research, "George Emil Palade" University of Medicine.
  • Ghiga DV; Department of Medical Informatics and Biostatistics, "George Emil Palade" University of Medicine.
  • Modi V; Department of Obstetrics and Gynecology, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology Târgu Mures, Gheorghe Marinescu street no 38, Târgu Mures, Romania.
  • Marginean C; Department of Obstetrics and Gynecology, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology Târgu Mures, Gheorghe Marinescu street no 38, Târgu Mures, Romania.
Medicine (Baltimore) ; 100(5): e24511, 2021 Feb 05.
Article en En | MEDLINE | ID: mdl-33592904
ABSTRACT: Pregnant women with excessive gestational weight gain express an inflammatory status with multiple negative effects on birth outcomes.The aim of this study was to identify the relationship between gestational weight gain at different gestational ages and inflammatory status in pregnant women and their newborns assessing both interleukin 6 and 8, as well as hepcidin in these couples.Our study included 170 pregnant women and their newborns. Pregnant women were clinically assessed at the end of the 1st trimester and at term, whereas the newborns were assessed over the first 3 days of life. The levels of interleukin 6, 8 and hepcidin were measured in both pregnant women and their newborns.We noticed higher levels of interleukin 6, interleukin 8 and hepcidin in pregnant women at the time of delivery as compared to the end of the 1st trimester. We observed a direct significant correlation between gestational weight gain at the time of delivery and interleukin 8 in both mothers [r = 0.1834, 95% CI: 0.0293-0.3290, (P = .0167)] and newborns [r = 0.1790, 95% CI: 0.0248-0.3249, (P = .0195)]. Our study underlined that a higher gestational weight gain resulted in a significantly higher birth weight [r = 0.2190, 95% CI: 0.0663-0.3617, (P = .0041)].Our findings suggest that interleukin 8 might be an important indicator of inflammatory status in both mothers and newborns. Moreover, excessive gestational weight gain was associated with an increase in birth weight.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peso al Nacer / Mediadores de Inflamación / Ganancia de Peso Gestacional Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Medicine (Baltimore) Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peso al Nacer / Mediadores de Inflamación / Ganancia de Peso Gestacional Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Medicine (Baltimore) Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos