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Single- and Multimarker Genome-Wide Scans Evidence Novel Genetic Risk Modifiers for Venous Thromboembolism.
Herrera-Rivero, Marisol; Stoll, Monika; Hegenbarth, Jana-Charlotte; Rühle, Frank; Limperger, Verena; Junker, Ralf; Franke, André; Hoffmann, Per; Shneyder, Maria; Stach, Michael; Nowak-Göttl, Ulrike.
Afiliación
  • Herrera-Rivero M; Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany.
  • Stoll M; Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany.
  • Hegenbarth JC; Department of Biochemistry, Genetic Epidemiology and Statistical Genetics, Maastricht University, Maastricht, The Netherlands.
  • Rühle F; Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany.
  • Limperger V; Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany.
  • Junker R; Institute for Clinical Chemistry and Coagulation Center, University Hospital Schleswig Holstein, Kiel/Lübeck, Germany.
  • Franke A; Institute for Clinical Chemistry and Coagulation Center, University Hospital Schleswig Holstein, Kiel/Lübeck, Germany.
  • Hoffmann P; Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Kiel, Germany.
  • Shneyder M; Life and Brain Research Centre, University of Bonn, Bonn, Germany.
  • Stach M; Institute for Clinical Chemistry and Coagulation Center, University Hospital Schleswig Holstein, Kiel/Lübeck, Germany.
  • Nowak-Göttl U; IT Service Centre, University Hospital Münster, Münster, Germany.
Thromb Haemost ; 121(9): 1169-1180, 2021 Sep.
Article en En | MEDLINE | ID: mdl-33592630
Previous genome-wide association studies (GWASs) have established several susceptibility genes for venous thromboembolism (VTE) and suggested many others. However, a large proportion of the genetic variance in VTE remains unexplained. Here, we report genome-wide single- and multimarker as well as gene-level associations with VTE in 964 cases and 899 healthy controls of European ancestry. We report 19 loci at the genome-wide level of association (p ≤ 5 × 10-8). Our results add to the strong support for the association of genetic variants in F5, NME7, ABO, and FGA with VTE, and identify several loci that have not been previously associated with VTE. Altogether, our novel findings suggest that 20 susceptibility genes for VTE were newly discovered by our study. These genes may impact the production and prothrombotic functions of platelets, endothelial cells, and white and red blood cells. Moreover, the majority of these genes have been previously associated with cardiovascular diseases and/or risk factors for VTE. Future studies are warranted to validate our findings and to investigate the shared genetic architecture with susceptibility factors for other cardiovascular diseases impacting VTE risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Tromboembolia Venosa / Sitios Genéticos Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Thromb Haemost Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Tromboembolia Venosa / Sitios Genéticos Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Thromb Haemost Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania