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Case Report: A 64-Year-Old Man with 10-Year History of Eosinophilic Granulomatosis with Polyangiitis with Bronchiectasis and Severe Klebsiella pneumonia.
Medvedev, Ivan; Podzolkov, Valery I; Ishina, Tatiana I; Pisarev, Mikhail V.
Afiliación
  • Medvedev I; Chair of Internal Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
  • Podzolkov VI; Chair of Internal Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
  • Ishina TI; Chair of Internal Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
  • Pisarev MV; Laboratory for the Study of Advanced Simulation Technologies, V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation.
Am J Case Rep ; 22: e929224, 2021 Feb 14.
Article en En | MEDLINE | ID: mdl-33582702
BACKGROUND Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and severe progressive disease with multiple clinical manifestations and organ damage. Usually, it requires long-term monitoring of the state of many organs due to the gradual character of its manifestations. CASE REPORT We report a case of a long-term follow-up of a patient with eosinophilic granulomatosis with polyangiitis with emphasis on specific clinical features in this patient. A 64-year-old man was being followed up for 10 years. The initial diagnosis was allergic bronchial asthma; however, as new clinical signs and symptoms developed, the diagnosis of EGPA became obvious. A positive treatment response was seen, mainly manifested as reduced polyneuropathy. Meanwhile, bronchial asthma remained uncontrolled and bronchiectasis and Klebsiella pneumoniae colonization developed despite the combination treatment with prednisolone and methotrexate. Furthermore, the patient suffered a cerebral ischemic infarction. During the last hospital admission, severe uncontrolled bronchial asthma complicated with pneumonia resulted in the patient's death. CONCLUSIONS This clinical case shows the gradual development of EGPA with multiple-organ involvement, including respiratory manifestations and peripheral and central nervous system damage. Immunosuppressive treatment combined with complications of EGPA could have contributed to severe pneumonia development and death of the patient.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Bronquiectasia / Síndrome de Churg-Strauss / Granulomatosis con Poliangitis Tipo de estudio: Diagnostic_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Am J Case Rep Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Bronquiectasia / Síndrome de Churg-Strauss / Granulomatosis con Poliangitis Tipo de estudio: Diagnostic_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Am J Case Rep Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos