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The variability of MR axon radii estimates in the human white matter.
Veraart, Jelle; Raven, Erika P; Edwards, Luke J; Weiskopf, Nikolaus; Jones, Derek K.
Afiliación
  • Veraart J; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.
  • Raven EP; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.
  • Edwards LJ; CUBRIC, School of Psychology, Cardiff University, Cardiff, UK.
  • Weiskopf N; Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
  • Jones DK; Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Hum Brain Mapp ; 42(7): 2201-2213, 2021 05.
Article en En | MEDLINE | ID: mdl-33576105
The noninvasive quantification of axonal morphology is an exciting avenue for gaining understanding of the function and structure of the central nervous system. Accurate non-invasive mapping of micron-sized axon radii using commonly applied neuroimaging techniques, that is, diffusion-weighted MRI, has been bolstered by recent hardware developments, specifically MR gradient design. Here the whole brain characterization of the effective MR axon radius is presented and the inter- and intra-scanner test-retest repeatability and reproducibility are evaluated to promote the further development of the effective MR axon radius as a neuroimaging biomarker. A coefficient-of-variability of approximately 10% in the voxelwise estimation of the effective MR radius is observed in the test-retest analysis, but it is shown that the performance can be improved fourfold using a customized along-tract analysis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Axones / Encéfalo / Imagen de Difusión por Resonancia Magnética / Neuroimagen / Sustancia Blanca Límite: Adult / Humans Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Axones / Encéfalo / Imagen de Difusión por Resonancia Magnética / Neuroimagen / Sustancia Blanca Límite: Adult / Humans Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos