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An antibacterial coated polymer prevents biofilm formation and implant-associated infection.
Ishihama, Hiroko; Ishii, Ken; Nagai, Shigenori; Kakinuma, Hiroaki; Sasaki, Aya; Yoshioka, Kenji; Kuramoto, Tetsuya; Shiono, Yuta; Funao, Haruki; Isogai, Norihiro; Tsuji, Takashi; Okada, Yasunori; Koyasu, Shigeo; Toyama, Yoshiaki; Nakamura, Masaya; Aizawa, Mamoru; Matsumoto, Morio.
Afiliación
  • Ishihama H; Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku, Tokyo, 160-8582, Japan.
  • Ishii K; Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku, Tokyo, 160-8582, Japan. kenishii88@gmail.com.
  • Nagai S; Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare (IUHW), 852 Hatakeda, Narita City, Chiba, 286-8520, Japan. kenishii88@gmail.com.
  • Kakinuma H; Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
  • Sasaki A; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo, Japan.
  • Yoshioka K; Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Kuramoto T; Department of Applied Chemistry, School of Science and Technology, Meiji University, Ikuta, Kanagawa, Japan.
  • Shiono Y; Kanagawa Academy of Science and Technology (KAST), Kawasaki, Kanagawa, Japan.
  • Funao H; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
  • Isogai N; Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku, Tokyo, 160-8582, Japan.
  • Tsuji T; Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku, Tokyo, 160-8582, Japan.
  • Okada Y; Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku, Tokyo, 160-8582, Japan.
  • Koyasu S; Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku, Tokyo, 160-8582, Japan.
  • Toyama Y; Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare (IUHW), 852 Hatakeda, Narita City, Chiba, 286-8520, Japan.
  • Nakamura M; Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku, Tokyo, 160-8582, Japan.
  • Aizawa M; Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare (IUHW), 852 Hatakeda, Narita City, Chiba, 286-8520, Japan.
  • Matsumoto M; Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku, Tokyo, 160-8582, Japan.
Sci Rep ; 11(1): 3602, 2021 02 11.
Article en En | MEDLINE | ID: mdl-33574464
To prevent infections associated with medical implants, various antimicrobial silver-coated implant materials have been developed. However, these materials do not always provide consistent antibacterial effects in vivo despite having dramatic antibacterial effects in vitro, probably because the antibacterial effects involve silver-ion-mediated reactive oxygen species generation. Additionally, the silver application process often requires extremely high temperatures, which damage non-metal implant materials. We recently developed a bacteria-resistant coating consisting of hydroxyapatite film on which ionic silver is immobilized via inositol hexaphosphate chelation, using a series of immersion and drying steps performed at low heat. Here we applied this coating to a polymer, polyetheretherketone (PEEK), and analyzed the properties and antibacterial activity of the coated polymer in vitro and in vivo. The ionic silver coating demonstrated significant bactericidal activity and prevented bacterial biofilm formation in vitro. Bio-imaging of a soft tissue infection mouse model in which a silver-coated PEEK plate was implanted revealed a dramatic absence of bacterial signals 10 days after inoculation. These animals also showed a strong reduction in histological features of infection, compared to the control animals. This innovative coating can be applied to complex structures for clinical use, and could prevent infections associated with a variety of plastic implants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis e Implantes / Infecciones Estafilocócicas / Biopelículas / Materiales Biocompatibles Revestidos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis e Implantes / Infecciones Estafilocócicas / Biopelículas / Materiales Biocompatibles Revestidos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido